Genetic association between serum 25-hydroxyvitamin D levels and lung function in Korean men and women: Data from KNHANES 2011–2012

Clara Yongjoo Park, So Young Kwak, Garam Jo, Min-Jeong Shin

Research output: Contribution to journalArticle

Abstract

The association between single-nucleotide polymorphisms (SNPs) in the vitamin D metabolic pathway and lung function is unknown. We examined the association between five SNPs on DHCR7, GC, CYP2R1, and CYP24A1 along with serum 25-hydroxyvitamin D (25(OH)D) levels and lung function in older Korean men (n = 758) and women (n = 837). Lung function was determined by forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) from the data in the Korea Nutrition and Health Examination Survey 2011–2012. Genetic risk score (GRS) was calculated by the number of 25(OH)D-decreasing alleles of the five SNPs. Our results showed that increases in GRS were associated with reduced 25(OH)D levels (p < 0.05 for both sexes). In the entire population, FVC and FEV1 were associated with both GRS and 25(OH)D levels. In women, FVC and FEV1 were negatively associated with GRS (β-coefficient (95% CI): −0.022 (−0.039, −0.005) and −0.020 (−0.035, −0.005), respectively; both p < 0.05), but not with 25(OH)D. However, in men, FVC and FEV1 were positively associated with 25(OH)D (β-coefficient (95% CI): 0.008 (0.001, 0.016) and 0.008 (0.002, 0.015), respectively; both p < 0.05), but not with GRS. In conclusion, lung function was associated with genetic variation in Korean women and with 25(OH)D in Korean men.

Original languageEnglish
Article number1362
JournalNutrients
Volume10
Issue number10
DOIs
Publication statusPublished - 2018 Oct 1

Keywords

  • FEV1
  • FVC
  • KNHANES
  • Lung function
  • Single-nucleotide polymorphism
  • Vitamin D

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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