Genetic distribution of group A human rotavirus types isolated in Gyunggi province of Korea, 1999-2002

Sung Sil Moon, Yangsook Song Green, Jin Won Song, Chang Nam Ahn, Hoon Kim, Kwang Sook Park, Ki Joon Song, Jung Hwa Lee, Luck Ju Baek

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Background: Human rotavirus genotypes G1-G4 and G9 are the major etiological agents of infantile gastroenteritis. G1 was the most prevalent in Korea during the 10-year period prior to 1997. However, between 1998 and 1999, G4 was the predominant type in Korea, as it was in other Asian countries. Objectives: The circulating pattern and genetic variability of group A human rotavirus in Gyunggi, Korea, 1999-2002, were examined in 189 stool specimens. Study design: Stool samples were collected from children with diarrhea, and group A human rotavirus type was determined using multiplex RT-PCR in those specimens found to be positive for rotavirus by ELISA. Each genotype was sequenced, and phylogenetic analysis was performed on the sequences. Result: We found significant variability from year to year in the prevalence of different G and P types of rotavirus. We also found relatively high prevalence rates for types normally considered to be uncommon. Furthermore, we found that the most prevalent combination of G and P types changed from year to year. Although the combination of G and P types changed every year, the sequence of G genotypes showed a high level of similarity (>97%) compared to those of strains from other Asian countries. Conclusion: We report the types of rotavirus circulating in Gyunggi province, Korea from 1999 to 2002. This information on rotavirus diversity has important implications for rotavirus vaccine efficacy and future vaccine development.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalJournal of Clinical Virology
Issue number1
Publication statusPublished - 2007 Jan


  • Genotype
  • Group A human rotavirus
  • Phylogenetic analysis
  • VP4 (P)
  • VP7 (G)

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


Dive into the research topics of 'Genetic distribution of group A human rotavirus types isolated in Gyunggi province of Korea, 1999-2002'. Together they form a unique fingerprint.

Cite this