Genetic diversity of Apodemus agrarius-Borne Hantaan virus in Korea

Jin Won Song, L. J. Baek, S. H. Kim, E. Y. Kho, J. H. Kim, R. Yanagihara, Ki-Joon Song

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Hantaan (HTN) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (HFRS), was first isolated in 1976 from lung tissues of striped field mice (Apodemus agrarius) captured in Songnae-ri, Kyungki-do, Korea. To clarify the genetic diversity and phylogenetic relationship among Korean strains of HTN virus, viral sequences of the partial S and M segments were amplified from lung tissues of 24 seropositive striped field mice captured between 1989 and 1998 at 11 sites in South Korea. The 771-nucleotide (nt) S segment sequences (coordinates 432 to 1202) of HTN virus strains from Yangju-kun differed by 10 to 40nt (1.3 to 5.2%) from virus strains from Pocheon-kun, Songnae-ri and Nonsan-kun. Similar degrees of genetic variation were found in the G1 and G2 glycoprotein-encoding M segment. Phylogenetic trees, based on the partial S and M segments and generated by the maximum parsimony and neighbor-joining methods, demonstrated that virus strains from various geographic regions in South Korea showed a tendency to form two phylogenetic subgroups and were evolutionarily distinct from HTN virus strains from the People's Republic of China.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalVirus Genes
Volume21
Issue number3
DOIs
Publication statusPublished - 2000 Dec 18

Fingerprint

Hantaan virus
Murinae
Korea
Republic of Korea
Hemorrhagic Fever with Renal Syndrome
Viruses
Lung
China
Glycoproteins
Nucleotides

Keywords

  • Genetic diversity
  • Hantaan virus
  • Hantavirus
  • RT-PCR

ASJC Scopus subject areas

  • Virology
  • Molecular Biology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Genetics

Cite this

Genetic diversity of Apodemus agrarius-Borne Hantaan virus in Korea. / Song, Jin Won; Baek, L. J.; Kim, S. H.; Kho, E. Y.; Kim, J. H.; Yanagihara, R.; Song, Ki-Joon.

In: Virus Genes, Vol. 21, No. 3, 18.12.2000, p. 227-232.

Research output: Contribution to journalArticle

Song, JW, Baek, LJ, Kim, SH, Kho, EY, Kim, JH, Yanagihara, R & Song, K-J 2000, 'Genetic diversity of Apodemus agrarius-Borne Hantaan virus in Korea', Virus Genes, vol. 21, no. 3, pp. 227-232. https://doi.org/10.1023/A:1008199800011
Song JW, Baek LJ, Kim SH, Kho EY, Kim JH, Yanagihara R et al. Genetic diversity of Apodemus agrarius-Borne Hantaan virus in Korea. Virus Genes. 2000 Dec 18;21(3):227-232. https://doi.org/10.1023/A:1008199800011
Song, Jin Won ; Baek, L. J. ; Kim, S. H. ; Kho, E. Y. ; Kim, J. H. ; Yanagihara, R. ; Song, Ki-Joon. / Genetic diversity of Apodemus agrarius-Borne Hantaan virus in Korea. In: Virus Genes. 2000 ; Vol. 21, No. 3. pp. 227-232.
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