Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004-2010

Se Hun Gu; Hae Ji Kang; Luck Ju Baek; Ji Yun Noh; Heung Chul Kim; Terry A. Klein; Richard Yanagihara; Jin Won Song

doi:10.1186/1743-422X-8-56

Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004-2010

Se Hun Gu, Hae Ji Kang, Luck Ju Baek, Ji Yun Noh, Heung Chul Kim, Terry A. Klein, Richard Yanagihara, Jin Won Song

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Recently, Imjin virus (MJNV), a genetically distinct hantavirus, was isolated from lung tissues of the Ussuri white-toothed shrew (Crocidura lasiura) captured near the demilitarized zone in the Republic of Korea. To clarify the genetic diversity of MJNV, partial M- and L-segment sequences were amplified from lung tissues of 12 of 37 (32.4%) anti-MJNV IgG antibody-positive Ussuri white-toothed shrews captured between 2004 and 2010. A 531-nucleotide region of the M segment (coordinates 2,255 to 2,785) revealed that the 12 MJNV strains differed by 0-12.2% and 0-2.3% at the nucleotide and amino acid levels, respectively. A similar degree of nucleotide (0.2-11.9%) and amino acid (0-3.8%) difference was found in a 632-nucleotide length of the L segment (coordinates 962 to 1,593) of nine MJNV strains. Phylogenetic analyses, based on the partial M and L segments of MJNV strains generated by the neighbor-joining and maximum likelihood methods, showed geographic-specific clustering, akin to the phylogeography of rodent-borne hantaviruses.

Original language	English
Article number	56
Journal	Virology Journal
Volume	8
DOIs	https://doi.org/10.1186/1743-422X-8-56
Publication status	Published - 2011
Externally published	Yes

ASJC Scopus subject areas

Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1743-422X-8-56

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@article{66d1b1abda974ba1a376129fc7d9e9a8,

title = "Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004-2010",

abstract = "Recently, Imjin virus (MJNV), a genetically distinct hantavirus, was isolated from lung tissues of the Ussuri white-toothed shrew (Crocidura lasiura) captured near the demilitarized zone in the Republic of Korea. To clarify the genetic diversity of MJNV, partial M- and L-segment sequences were amplified from lung tissues of 12 of 37 (32.4%) anti-MJNV IgG antibody-positive Ussuri white-toothed shrews captured between 2004 and 2010. A 531-nucleotide region of the M segment (coordinates 2,255 to 2,785) revealed that the 12 MJNV strains differed by 0-12.2% and 0-2.3% at the nucleotide and amino acid levels, respectively. A similar degree of nucleotide (0.2-11.9%) and amino acid (0-3.8%) difference was found in a 632-nucleotide length of the L segment (coordinates 962 to 1,593) of nine MJNV strains. Phylogenetic analyses, based on the partial M and L segments of MJNV strains generated by the neighbor-joining and maximum likelihood methods, showed geographic-specific clustering, akin to the phylogeography of rodent-borne hantaviruses.",

author = "Gu, {Se Hun} and Kang, {Hae Ji} and Baek, {Luck Ju} and Noh, {Ji Yun} and Kim, {Heung Chul} and Klein, {Terry A.} and Richard Yanagihara and Song, {Jin Won}",

note = "Funding Information: This work was supported in part by U.S. Public Health Service grants from the National Institute of Allergy and Infectious Diseases (R01AI075057) and the National Center for Research Resources (P2RR018727 and G12RR003061), National Institutes of Health, and grants from the U.S Department of Defense, Global Emerging Infectious Surveillance and Response System (GEIS), and the Armed Forces Medical Intelligence Center (AFMIC).",

year = "2011",

doi = "10.1186/1743-422X-8-56",

language = "English",

volume = "8",

journal = "Virology Journal",

issn = "1743-422X",

publisher = "BioMed Central",

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TY - JOUR

T1 - Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004-2010

AU - Gu, Se Hun

AU - Kang, Hae Ji

AU - Baek, Luck Ju

AU - Noh, Ji Yun

AU - Kim, Heung Chul

AU - Klein, Terry A.

AU - Yanagihara, Richard

AU - Song, Jin Won

N1 - Funding Information: This work was supported in part by U.S. Public Health Service grants from the National Institute of Allergy and Infectious Diseases (R01AI075057) and the National Center for Research Resources (P2RR018727 and G12RR003061), National Institutes of Health, and grants from the U.S Department of Defense, Global Emerging Infectious Surveillance and Response System (GEIS), and the Armed Forces Medical Intelligence Center (AFMIC).

PY - 2011

Y1 - 2011

N2 - Recently, Imjin virus (MJNV), a genetically distinct hantavirus, was isolated from lung tissues of the Ussuri white-toothed shrew (Crocidura lasiura) captured near the demilitarized zone in the Republic of Korea. To clarify the genetic diversity of MJNV, partial M- and L-segment sequences were amplified from lung tissues of 12 of 37 (32.4%) anti-MJNV IgG antibody-positive Ussuri white-toothed shrews captured between 2004 and 2010. A 531-nucleotide region of the M segment (coordinates 2,255 to 2,785) revealed that the 12 MJNV strains differed by 0-12.2% and 0-2.3% at the nucleotide and amino acid levels, respectively. A similar degree of nucleotide (0.2-11.9%) and amino acid (0-3.8%) difference was found in a 632-nucleotide length of the L segment (coordinates 962 to 1,593) of nine MJNV strains. Phylogenetic analyses, based on the partial M and L segments of MJNV strains generated by the neighbor-joining and maximum likelihood methods, showed geographic-specific clustering, akin to the phylogeography of rodent-borne hantaviruses.

AB - Recently, Imjin virus (MJNV), a genetically distinct hantavirus, was isolated from lung tissues of the Ussuri white-toothed shrew (Crocidura lasiura) captured near the demilitarized zone in the Republic of Korea. To clarify the genetic diversity of MJNV, partial M- and L-segment sequences were amplified from lung tissues of 12 of 37 (32.4%) anti-MJNV IgG antibody-positive Ussuri white-toothed shrews captured between 2004 and 2010. A 531-nucleotide region of the M segment (coordinates 2,255 to 2,785) revealed that the 12 MJNV strains differed by 0-12.2% and 0-2.3% at the nucleotide and amino acid levels, respectively. A similar degree of nucleotide (0.2-11.9%) and amino acid (0-3.8%) difference was found in a 632-nucleotide length of the L segment (coordinates 962 to 1,593) of nine MJNV strains. Phylogenetic analyses, based on the partial M and L segments of MJNV strains generated by the neighbor-joining and maximum likelihood methods, showed geographic-specific clustering, akin to the phylogeography of rodent-borne hantaviruses.

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DO - 10.1186/1743-422X-8-56

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SN - 1743-422X

VL - 8

JO - Virology Journal

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Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004-2010

Abstract

ASJC Scopus subject areas

UN SDGs

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