Abstract
The Plasmodium vivax merozoite surface protein 1 (Pvmsp-1) locus codes for a major asexual blood-stage antigen currently proposed as a malaria vaccine candidate antigen. However, extensive polymorphism of this protein has been observed in isolates from different geographical areas. Here, we investigate the extent and the frequency of allelic diversity at the Pvmsp-1 locus in field isolates collected in the Republic of Korea during the past decade. Among the 45 Korean isolates, six Pvmsp-1 gene types (SKOR-I to SKOR-VI) were identified as unique combinations of type sequences in each variable block. Of these six different Pvmsp-1 gene types, two major Pvmsp-1 allelic types were found in 72% (SKOR-I) and 28% (SKOR-II) of field isolates collected in 1996 to 2000, and four different allelic types (SKOR-III to SKOR-VI) emerged in 70% (10-25%) of isolates collected in 2007 to 2009. These results suggest that allelic diversity of Pvmsp-1 increased in several variable regions, including the N- and C-terminals, after reemergence of P. vivax parasites in the Republic of Korea.
| Original language | English |
|---|---|
| Pages (from-to) | 1571-1576 |
| Number of pages | 6 |
| Journal | Parasitology Research |
| Volume | 109 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2011 Dec 1 |
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ASJC Scopus subject areas
- Parasitology
- Infectious Diseases
Cite this
Genetic diversity of the malaria vaccine candidate merozoite surface protein 1 gene of Plasmodium vivax field isolates in Republic of Korea. / Han, Eun Taek; Wang, Yue; Lim, Chae Seung; Cho, Jun Hwi; Chai, Jong Yil.
In: Parasitology Research, Vol. 109, No. 6, 01.12.2011, p. 1571-1576.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Genetic diversity of the malaria vaccine candidate merozoite surface protein 1 gene of Plasmodium vivax field isolates in Republic of Korea
AU - Han, Eun Taek
AU - Wang, Yue
AU - Lim, Chae Seung
AU - Cho, Jun Hwi
AU - Chai, Jong Yil
PY - 2011/12/1
Y1 - 2011/12/1
N2 - The Plasmodium vivax merozoite surface protein 1 (Pvmsp-1) locus codes for a major asexual blood-stage antigen currently proposed as a malaria vaccine candidate antigen. However, extensive polymorphism of this protein has been observed in isolates from different geographical areas. Here, we investigate the extent and the frequency of allelic diversity at the Pvmsp-1 locus in field isolates collected in the Republic of Korea during the past decade. Among the 45 Korean isolates, six Pvmsp-1 gene types (SKOR-I to SKOR-VI) were identified as unique combinations of type sequences in each variable block. Of these six different Pvmsp-1 gene types, two major Pvmsp-1 allelic types were found in 72% (SKOR-I) and 28% (SKOR-II) of field isolates collected in 1996 to 2000, and four different allelic types (SKOR-III to SKOR-VI) emerged in 70% (10-25%) of isolates collected in 2007 to 2009. These results suggest that allelic diversity of Pvmsp-1 increased in several variable regions, including the N- and C-terminals, after reemergence of P. vivax parasites in the Republic of Korea.
AB - The Plasmodium vivax merozoite surface protein 1 (Pvmsp-1) locus codes for a major asexual blood-stage antigen currently proposed as a malaria vaccine candidate antigen. However, extensive polymorphism of this protein has been observed in isolates from different geographical areas. Here, we investigate the extent and the frequency of allelic diversity at the Pvmsp-1 locus in field isolates collected in the Republic of Korea during the past decade. Among the 45 Korean isolates, six Pvmsp-1 gene types (SKOR-I to SKOR-VI) were identified as unique combinations of type sequences in each variable block. Of these six different Pvmsp-1 gene types, two major Pvmsp-1 allelic types were found in 72% (SKOR-I) and 28% (SKOR-II) of field isolates collected in 1996 to 2000, and four different allelic types (SKOR-III to SKOR-VI) emerged in 70% (10-25%) of isolates collected in 2007 to 2009. These results suggest that allelic diversity of Pvmsp-1 increased in several variable regions, including the N- and C-terminals, after reemergence of P. vivax parasites in the Republic of Korea.
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UR - http://www.scopus.com/inward/citedby.url?scp=83055179744&partnerID=8YFLogxK
U2 - 10.1007/s00436-011-2413-5
DO - 10.1007/s00436-011-2413-5
M3 - Article
C2 - 21556687
AN - SCOPUS:83055179744
VL - 109
SP - 1571
EP - 1576
JO - Parasitology Research
JF - Parasitology Research
SN - 0932-0113
IS - 6
ER -