Genetic effects on urinary 1-hydroxypyrene levels in a Korean population

Mihi Yang, Jae Yeon Jang, Soyeon Kim, Su Man Lee, Seong Sil Chang, Hae Kwan Cheong, Eun Il Lee, Daehee Kang, Ho Kim, Toshihiro Kawamoto, Hyoung Doo Shin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Urinary 1-hydroxypyrene (1-OHP) has been used as a biomarker for assessing the level of exposure to environmental carcinogenic polycyclic aromatic hydrocarbons (PAHs). In order to perform the appropriate biological monitoring for examining the level of exposure to PAHs, this study investigated whether or not genetic polymorphisms of the metabolic enzymes, which might be involved in the metabolism of pyrene, affected the urinary 1-OHP levels in a population of 661 Koreans (male, 63%; female, 37%; mean age, 36.5 ± 11.1 years) who were not occupationally exposed to PAHs. Urinary 1-OHP was detected in 76% of the subjects (range 0.001-3.8 μg/l). Among the physical and lifestyle factors, cigarette-smoking was found to be associated with the urinary 1-OHP levels (P < 0.05). After adjusting for these factors, we found that the GSTT1 genotypes affected the urinary 1-OHP levels, i.e. the GSTT1 present subjects had ∼1.5 times the urinary 1-OHP level than the GSTT1 null subjects (P < 0.05). In the case of the subjects who were also GSTM1 null, this trend became stronger, i.e. the GSTT1 present subjects had ∼2 times the urinary 1-OHP level (P < 0.01). However, the genetic polymorphism of the other metabolic enzymes, cytochrome P-450 (CYP)1A1, CYP1B1 and GSTM1 alone, did not affect the urinary 1-OHP level. Therefore, this study suggests that the GSTT1 genetic polymorphism has the potential to affect the biological monitoring of PAHs with urinary 1-OHP, and might act as a genetic factor in PAH-related toxicity.

Original languageEnglish
Pages (from-to)1085-1089
Number of pages5
JournalCarcinogenesis
Volume24
Issue number6
Publication statusPublished - 2003 Jun 1

Fingerprint

Polycyclic Aromatic Hydrocarbons
Genetic Polymorphisms
Population
Environmental Monitoring
Environmental Exposure
Enzymes
Life Style
Biomarkers
Smoking
Genotype
1-hydroxypyrene

ASJC Scopus subject areas

  • Cancer Research

Cite this

Yang, M., Jang, J. Y., Kim, S., Lee, S. M., Chang, S. S., Cheong, H. K., ... Doo Shin, H. (2003). Genetic effects on urinary 1-hydroxypyrene levels in a Korean population. Carcinogenesis, 24(6), 1085-1089.

Genetic effects on urinary 1-hydroxypyrene levels in a Korean population. / Yang, Mihi; Jang, Jae Yeon; Kim, Soyeon; Lee, Su Man; Chang, Seong Sil; Cheong, Hae Kwan; Lee, Eun Il; Kang, Daehee; Kim, Ho; Kawamoto, Toshihiro; Doo Shin, Hyoung.

In: Carcinogenesis, Vol. 24, No. 6, 01.06.2003, p. 1085-1089.

Research output: Contribution to journalArticle

Yang, M, Jang, JY, Kim, S, Lee, SM, Chang, SS, Cheong, HK, Lee, EI, Kang, D, Kim, H, Kawamoto, T & Doo Shin, H 2003, 'Genetic effects on urinary 1-hydroxypyrene levels in a Korean population', Carcinogenesis, vol. 24, no. 6, pp. 1085-1089.
Yang M, Jang JY, Kim S, Lee SM, Chang SS, Cheong HK et al. Genetic effects on urinary 1-hydroxypyrene levels in a Korean population. Carcinogenesis. 2003 Jun 1;24(6):1085-1089.
Yang, Mihi ; Jang, Jae Yeon ; Kim, Soyeon ; Lee, Su Man ; Chang, Seong Sil ; Cheong, Hae Kwan ; Lee, Eun Il ; Kang, Daehee ; Kim, Ho ; Kawamoto, Toshihiro ; Doo Shin, Hyoung. / Genetic effects on urinary 1-hydroxypyrene levels in a Korean population. In: Carcinogenesis. 2003 ; Vol. 24, No. 6. pp. 1085-1089.
@article{972c0df2e4004abeb8b4e3bd23e1fa1c,
title = "Genetic effects on urinary 1-hydroxypyrene levels in a Korean population",
abstract = "Urinary 1-hydroxypyrene (1-OHP) has been used as a biomarker for assessing the level of exposure to environmental carcinogenic polycyclic aromatic hydrocarbons (PAHs). In order to perform the appropriate biological monitoring for examining the level of exposure to PAHs, this study investigated whether or not genetic polymorphisms of the metabolic enzymes, which might be involved in the metabolism of pyrene, affected the urinary 1-OHP levels in a population of 661 Koreans (male, 63{\%}; female, 37{\%}; mean age, 36.5 ± 11.1 years) who were not occupationally exposed to PAHs. Urinary 1-OHP was detected in 76{\%} of the subjects (range 0.001-3.8 μg/l). Among the physical and lifestyle factors, cigarette-smoking was found to be associated with the urinary 1-OHP levels (P < 0.05). After adjusting for these factors, we found that the GSTT1 genotypes affected the urinary 1-OHP levels, i.e. the GSTT1 present subjects had ∼1.5 times the urinary 1-OHP level than the GSTT1 null subjects (P < 0.05). In the case of the subjects who were also GSTM1 null, this trend became stronger, i.e. the GSTT1 present subjects had ∼2 times the urinary 1-OHP level (P < 0.01). However, the genetic polymorphism of the other metabolic enzymes, cytochrome P-450 (CYP)1A1, CYP1B1 and GSTM1 alone, did not affect the urinary 1-OHP level. Therefore, this study suggests that the GSTT1 genetic polymorphism has the potential to affect the biological monitoring of PAHs with urinary 1-OHP, and might act as a genetic factor in PAH-related toxicity.",
author = "Mihi Yang and Jang, {Jae Yeon} and Soyeon Kim and Lee, {Su Man} and Chang, {Seong Sil} and Cheong, {Hae Kwan} and Lee, {Eun Il} and Daehee Kang and Ho Kim and Toshihiro Kawamoto and {Doo Shin}, Hyoung",
year = "2003",
month = "6",
day = "1",
language = "English",
volume = "24",
pages = "1085--1089",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Genetic effects on urinary 1-hydroxypyrene levels in a Korean population

AU - Yang, Mihi

AU - Jang, Jae Yeon

AU - Kim, Soyeon

AU - Lee, Su Man

AU - Chang, Seong Sil

AU - Cheong, Hae Kwan

AU - Lee, Eun Il

AU - Kang, Daehee

AU - Kim, Ho

AU - Kawamoto, Toshihiro

AU - Doo Shin, Hyoung

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Urinary 1-hydroxypyrene (1-OHP) has been used as a biomarker for assessing the level of exposure to environmental carcinogenic polycyclic aromatic hydrocarbons (PAHs). In order to perform the appropriate biological monitoring for examining the level of exposure to PAHs, this study investigated whether or not genetic polymorphisms of the metabolic enzymes, which might be involved in the metabolism of pyrene, affected the urinary 1-OHP levels in a population of 661 Koreans (male, 63%; female, 37%; mean age, 36.5 ± 11.1 years) who were not occupationally exposed to PAHs. Urinary 1-OHP was detected in 76% of the subjects (range 0.001-3.8 μg/l). Among the physical and lifestyle factors, cigarette-smoking was found to be associated with the urinary 1-OHP levels (P < 0.05). After adjusting for these factors, we found that the GSTT1 genotypes affected the urinary 1-OHP levels, i.e. the GSTT1 present subjects had ∼1.5 times the urinary 1-OHP level than the GSTT1 null subjects (P < 0.05). In the case of the subjects who were also GSTM1 null, this trend became stronger, i.e. the GSTT1 present subjects had ∼2 times the urinary 1-OHP level (P < 0.01). However, the genetic polymorphism of the other metabolic enzymes, cytochrome P-450 (CYP)1A1, CYP1B1 and GSTM1 alone, did not affect the urinary 1-OHP level. Therefore, this study suggests that the GSTT1 genetic polymorphism has the potential to affect the biological monitoring of PAHs with urinary 1-OHP, and might act as a genetic factor in PAH-related toxicity.

AB - Urinary 1-hydroxypyrene (1-OHP) has been used as a biomarker for assessing the level of exposure to environmental carcinogenic polycyclic aromatic hydrocarbons (PAHs). In order to perform the appropriate biological monitoring for examining the level of exposure to PAHs, this study investigated whether or not genetic polymorphisms of the metabolic enzymes, which might be involved in the metabolism of pyrene, affected the urinary 1-OHP levels in a population of 661 Koreans (male, 63%; female, 37%; mean age, 36.5 ± 11.1 years) who were not occupationally exposed to PAHs. Urinary 1-OHP was detected in 76% of the subjects (range 0.001-3.8 μg/l). Among the physical and lifestyle factors, cigarette-smoking was found to be associated with the urinary 1-OHP levels (P < 0.05). After adjusting for these factors, we found that the GSTT1 genotypes affected the urinary 1-OHP levels, i.e. the GSTT1 present subjects had ∼1.5 times the urinary 1-OHP level than the GSTT1 null subjects (P < 0.05). In the case of the subjects who were also GSTM1 null, this trend became stronger, i.e. the GSTT1 present subjects had ∼2 times the urinary 1-OHP level (P < 0.01). However, the genetic polymorphism of the other metabolic enzymes, cytochrome P-450 (CYP)1A1, CYP1B1 and GSTM1 alone, did not affect the urinary 1-OHP level. Therefore, this study suggests that the GSTT1 genetic polymorphism has the potential to affect the biological monitoring of PAHs with urinary 1-OHP, and might act as a genetic factor in PAH-related toxicity.

UR - http://www.scopus.com/inward/record.url?scp=0038349214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038349214&partnerID=8YFLogxK

M3 - Article

C2 - 12807751

AN - SCOPUS:0038349214

VL - 24

SP - 1085

EP - 1089

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 6

ER -