Genetic influences on neonatal cortical thickness and surface area

Shaili C. Jha, Kai Xia, James Eric Schmitt, Mihye Ahn, Jessica B. Girault, Veronica A. Murphy, Gang Li, Li Wang, Dinggang Shen, Fei Zou, Hongtu Zhu, Martin Styner, Rebecca C. Knickmeyer, John H. Gilmore

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Genetic and environmental influences on cortical thickness (CT) and surface area (SA) are thought to vary in a complex and dynamic way across the lifespan. It has been established that CT and SA are genetically distinct in older children, adolescents, and adults, and that heritability varies across cortical regions. Very little, however, is known about how genetic and environmental factors influence infant CT and SA. Using structural MRI, we performed the first assessment of genetic and environmental influences on normal variation of SA and CT in 360 twin neonates. We observed strong and significant additive genetic influences on total SA (a2 = 0.78) and small and nonsignificant genetic influences on average CT (a2 = 0.29). Moreover, we found significant genetic overlap (genetic correlation = 0.65) between these global cortical measures. Regionally, there were minimal genetic influences across the cortex for both CT and SA measures and no distinct patterns of genetic regionalization. Overall, outcomes from this study suggest a dynamic relationship between CT and SA during the neonatal period and provide novel insights into how genetic influences shape cortical structure during early development.

Original languageEnglish
JournalHuman Brain Mapping
DOIs
Publication statusAccepted/In press - 2018 Jan 1
Externally publishedYes

Fingerprint

Outcome Assessment (Health Care)
Newborn Infant

Keywords

  • brain development
  • gray matter
  • heritability
  • infant
  • MRI
  • twin

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Jha, S. C., Xia, K., Schmitt, J. E., Ahn, M., Girault, J. B., Murphy, V. A., ... Gilmore, J. H. (Accepted/In press). Genetic influences on neonatal cortical thickness and surface area. Human Brain Mapping. https://doi.org/10.1002/hbm.24340

Genetic influences on neonatal cortical thickness and surface area. / Jha, Shaili C.; Xia, Kai; Schmitt, James Eric; Ahn, Mihye; Girault, Jessica B.; Murphy, Veronica A.; Li, Gang; Wang, Li; Shen, Dinggang; Zou, Fei; Zhu, Hongtu; Styner, Martin; Knickmeyer, Rebecca C.; Gilmore, John H.

In: Human Brain Mapping, 01.01.2018.

Research output: Contribution to journalArticle

Jha, SC, Xia, K, Schmitt, JE, Ahn, M, Girault, JB, Murphy, VA, Li, G, Wang, L, Shen, D, Zou, F, Zhu, H, Styner, M, Knickmeyer, RC & Gilmore, JH 2018, 'Genetic influences on neonatal cortical thickness and surface area', Human Brain Mapping. https://doi.org/10.1002/hbm.24340
Jha SC, Xia K, Schmitt JE, Ahn M, Girault JB, Murphy VA et al. Genetic influences on neonatal cortical thickness and surface area. Human Brain Mapping. 2018 Jan 1. https://doi.org/10.1002/hbm.24340
Jha, Shaili C. ; Xia, Kai ; Schmitt, James Eric ; Ahn, Mihye ; Girault, Jessica B. ; Murphy, Veronica A. ; Li, Gang ; Wang, Li ; Shen, Dinggang ; Zou, Fei ; Zhu, Hongtu ; Styner, Martin ; Knickmeyer, Rebecca C. ; Gilmore, John H. / Genetic influences on neonatal cortical thickness and surface area. In: Human Brain Mapping. 2018.
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