Genetic polymorphism of Plasmodium vivax msp1p, a paralog of merozoite surface protein 1, from worldwide isolates

Yue Wang, Osamu Kaneko, Jetsumon Sattabongkot, Jun Hu Chen, Feng Lu, Jong Yil Chai, Satoru Takeo, Takafumi Tsuboi, Francisco J. Ayala, Yong Chen, Chae Seung Lim, Eun Taek Han

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Plasmodium vivax msp1p, a paralog of the candidate vaccine antigen P. vivax merozoite surface protein 1, possesses a signal peptide at its N-terminus and two epidermal growth factor-like domains at its C-terminus with a glycosylphosphatidylinositol attachment site. The msp1p gene locus may have originated by a duplication of the msp1 gene locus in a common ancestor of the analyzed Plasmodium species and lost from P. yoelii, P. berghei, and P. falciparum during their evolutionary history. Full-length sequences of the msp1p gene were generally highly conserved; they had a few amino acid substitutions, one highly polymorphic E/Q-rich region, and a single-to-triple hepta-peptide repeat motif. Twenty-one distinguishable allelic types (A1-A21) of the E/Q-rich region were identified from worldwide isolates. Among them, four types were detected in isolates from South Korea. The length polymorphism of the E/Q-rich region might be useful as a genetic marker for population structure studies in malaria-endemic areas.

Original languageEnglish
Pages (from-to)292-297
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume84
Issue number2
DOIs
Publication statusPublished - 2011 Feb

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Genetic polymorphism of Plasmodium vivax msp1p, a paralog of merozoite surface protein 1, from worldwide isolates'. Together they form a unique fingerprint.

  • Cite this

    Wang, Y., Kaneko, O., Sattabongkot, J., Chen, J. H., Lu, F., Chai, J. Y., Takeo, S., Tsuboi, T., Ayala, F. J., Chen, Y., Lim, C. S., & Han, E. T. (2011). Genetic polymorphism of Plasmodium vivax msp1p, a paralog of merozoite surface protein 1, from worldwide isolates. American Journal of Tropical Medicine and Hygiene, 84(2), 292-297. https://doi.org/10.4269/ajtmh.2011.10-0432