Genetic polymorphism of the renin-angiotensin system on the development of primary vesicoureteral reflux

Hyung Eun Yim, Min Ji Jung, Byung Min Choi, In Sun Bae, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    Background: The familial clustering of vesicoureteral reflux (VUR) has suggested a genetic basis. This study was designed to investigate the genetic polymorphism of the renin-angiotensin system (RAS) in Korean children. Methods: Genetic polymorphism of angiotensin-converting enzyme (ACE) and angiotensin II receptor genes was evaluated in 67 primary VUR patients and compared to 58 controls with no urological abnormalities. To detect the relation of the risk factors of primary VUR with the genetic polymorphism, the distribution of ACE, AT1 and AT2 genotypes after stratification by risk factors was also studied in the primary VUR patients. Results: The incidence of AT2 A-1332G transition was significantly lower in primary VUR patients (p = 0.047). Furthermore, in the case of combination of ACE and AT2 gene, a significantly lower incidence of primary VUR was seen with II genotype of ACE and A-1332G transition in the AT2 receptor gene (p = 0.003). Concerning the risk factors of primary VUR, there were no biologically significant results. Conclusions: These findings indicate that a lower incidence of AT2 A-1332G transition is seen in primary VUR patients, at least in the Korean population. Also, in the case of combination of ACE and AT2 gene, the combination of ACE II genotype and AT2 A-1332G transition occurs infrequently in primary VUR.

    Original languageEnglish
    Pages (from-to)178-187
    Number of pages10
    JournalAmerican journal of nephrology
    Volume24
    Issue number2
    DOIs
    Publication statusPublished - 2004

    Keywords

    • Polymorphisms
    • Renin-angiotensin system
    • Vesicoureteral reflux

    ASJC Scopus subject areas

    • Nephrology

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