Genetic polymorphism of the renin-angiotensin system on the development of primary vesicoureteral reflux

Hyung-Eun Yim, Min Ji Jung, Byung Min Choi, In Sun Bae, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The familial clustering of vesicoureteral reflux (VUR) has suggested a genetic basis. This study was designed to investigate the genetic polymorphism of the renin-angiotensin system (RAS) in Korean children. Methods: Genetic polymorphism of angiotensin-converting enzyme (ACE) and angiotensin II receptor genes was evaluated in 67 primary VUR patients and compared to 58 controls with no urological abnormalities. To detect the relation of the risk factors of primary VUR with the genetic polymorphism, the distribution of ACE, AT1 and AT2 genotypes after stratification by risk factors was also studied in the primary VUR patients. Results: The incidence of AT2 A-1332G transition was significantly lower in primary VUR patients (p = 0.047). Furthermore, in the case of combination of ACE and AT2 gene, a significantly lower incidence of primary VUR was seen with II genotype of ACE and A-1332G transition in the AT2 receptor gene (p = 0.003). Concerning the risk factors of primary VUR, there were no biologically significant results. Conclusions: These findings indicate that a lower incidence of AT2 A-1332G transition is seen in primary VUR patients, at least in the Korean population. Also, in the case of combination of ACE and AT2 gene, the combination of ACE II genotype and AT2 A-1332G transition occurs infrequently in primary VUR.

Original languageEnglish
Pages (from-to)178-187
Number of pages10
JournalAmerican Journal of Nephrology
Volume24
Issue number2
DOIs
Publication statusPublished - 2004 Apr 21

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Vesico-Ureteral Reflux
Genetic Polymorphisms
Renin-Angiotensin System
Peptidyl-Dipeptidase A
Genotype
Genes
Incidence
Angiotensin Receptors
Cluster Analysis

Keywords

  • Polymorphisms
  • Renin-angiotensin system
  • Vesicoureteral reflux

ASJC Scopus subject areas

  • Nephrology

Cite this

Genetic polymorphism of the renin-angiotensin system on the development of primary vesicoureteral reflux. / Yim, Hyung-Eun; Jung, Min Ji; Choi, Byung Min; Bae, In Sun; Yoo, Kee Hwan; Hong, Young Sook; Lee, Joo Won; Kim, Soon Kyum.

In: American Journal of Nephrology, Vol. 24, No. 2, 21.04.2004, p. 178-187.

Research output: Contribution to journalArticle

Yim, Hyung-Eun ; Jung, Min Ji ; Choi, Byung Min ; Bae, In Sun ; Yoo, Kee Hwan ; Hong, Young Sook ; Lee, Joo Won ; Kim, Soon Kyum. / Genetic polymorphism of the renin-angiotensin system on the development of primary vesicoureteral reflux. In: American Journal of Nephrology. 2004 ; Vol. 24, No. 2. pp. 178-187.
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abstract = "Background: The familial clustering of vesicoureteral reflux (VUR) has suggested a genetic basis. This study was designed to investigate the genetic polymorphism of the renin-angiotensin system (RAS) in Korean children. Methods: Genetic polymorphism of angiotensin-converting enzyme (ACE) and angiotensin II receptor genes was evaluated in 67 primary VUR patients and compared to 58 controls with no urological abnormalities. To detect the relation of the risk factors of primary VUR with the genetic polymorphism, the distribution of ACE, AT1 and AT2 genotypes after stratification by risk factors was also studied in the primary VUR patients. Results: The incidence of AT2 A-1332G transition was significantly lower in primary VUR patients (p = 0.047). Furthermore, in the case of combination of ACE and AT2 gene, a significantly lower incidence of primary VUR was seen with II genotype of ACE and A-1332G transition in the AT2 receptor gene (p = 0.003). Concerning the risk factors of primary VUR, there were no biologically significant results. Conclusions: These findings indicate that a lower incidence of AT2 A-1332G transition is seen in primary VUR patients, at least in the Korean population. Also, in the case of combination of ACE and AT2 gene, the combination of ACE II genotype and AT2 A-1332G transition occurs infrequently in primary VUR.",
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AB - Background: The familial clustering of vesicoureteral reflux (VUR) has suggested a genetic basis. This study was designed to investigate the genetic polymorphism of the renin-angiotensin system (RAS) in Korean children. Methods: Genetic polymorphism of angiotensin-converting enzyme (ACE) and angiotensin II receptor genes was evaluated in 67 primary VUR patients and compared to 58 controls with no urological abnormalities. To detect the relation of the risk factors of primary VUR with the genetic polymorphism, the distribution of ACE, AT1 and AT2 genotypes after stratification by risk factors was also studied in the primary VUR patients. Results: The incidence of AT2 A-1332G transition was significantly lower in primary VUR patients (p = 0.047). Furthermore, in the case of combination of ACE and AT2 gene, a significantly lower incidence of primary VUR was seen with II genotype of ACE and A-1332G transition in the AT2 receptor gene (p = 0.003). Concerning the risk factors of primary VUR, there were no biologically significant results. Conclusions: These findings indicate that a lower incidence of AT2 A-1332G transition is seen in primary VUR patients, at least in the Korean population. Also, in the case of combination of ACE and AT2 gene, the combination of ACE II genotype and AT2 A-1332G transition occurs infrequently in primary VUR.

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