Genetic polymorphisms and linkage disequilibrium of sulfotransferase SULT1A1 and SULT1A2 in a Korean population: Comparison of other ethnic groups

Kyoung Ah Kim, Sook Young Lee, Pil Whan Park, Jong Myung Ha, Ji-Young Park

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aims: To determine the allele frequencies of sulfotransferases (SULTs) 1A1 and 1A2 and their linkage disequilibrium in a Korean population and compare them with those of other ethnic groups. Methods: Genotypes of the SULT1A1*1,*2, and*3 and SULT1A2*1,*2, and*3 allelic variants were determined in 234 Korean subjects using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) methods. Results: Allele frequencies for SULT1A1*1 and*2 were 0.876 [95% confidence interval (CI), 0.843-0.905] and 0.124 (95% CI, 0.096-0.157), respectively. Similarly, those for SULT1A2*1 and*2 were 0.885 (95% CI, 0.852-0.912) and 0.115 (95% CI, 0.088-0.150), respectively. However, no subject with SULT1A1*3 or SULT1A2*3 was detected. These genotype distributions are similar to those of Asian populations including the Chinese and Japanese, but quite different from other ethnic groups such as African-Americans and Caucasians. The expected allelic frequencies of SULT1A1 and SULT1A2 at Hardy-Weinberg equilibrium are quite similar to the observed distributions in the population. SULT1A1*2 and SULT1A2*2, the most common variant alleles of these two genes, are strongly and positively linked in the Korean population (D ′ =0.8919, χ2 =343.24, P=0.0034). Conclusions: SULT1A1*2 and SULT1A2*2 are the major allelic variants in the Korean population, whereas the SULT1A1*3 and SULT1A2*3 alleles were not found. SULT1A1*2 and SULT1A2*2 are strongly linked.

Original languageEnglish
Pages (from-to)743-747
Number of pages5
JournalEuropean Journal of Clinical Pharmacology
Volume61
Issue number10
DOIs
Publication statusPublished - 2005 Nov 1
Externally publishedYes

Fingerprint

Sulfotransferases
Genetic Linkage
Linkage Disequilibrium
Genetic Polymorphisms
Ethnic Groups
Confidence Intervals
Gene Frequency
Population
Alleles
Genotype
Restriction Fragment Length Polymorphisms
African Americans
Demography
Polymerase Chain Reaction
Genes

Keywords

  • Genetic polymorphism
  • Linkage disequilibrium
  • Sulfotransferase
  • SULT1A1
  • SULT1A2

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Genetic polymorphisms and linkage disequilibrium of sulfotransferase SULT1A1 and SULT1A2 in a Korean population : Comparison of other ethnic groups. / Kim, Kyoung Ah; Lee, Sook Young; Park, Pil Whan; Ha, Jong Myung; Park, Ji-Young.

In: European Journal of Clinical Pharmacology, Vol. 61, No. 10, 01.11.2005, p. 743-747.

Research output: Contribution to journalArticle

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title = "Genetic polymorphisms and linkage disequilibrium of sulfotransferase SULT1A1 and SULT1A2 in a Korean population: Comparison of other ethnic groups",
abstract = "Aims: To determine the allele frequencies of sulfotransferases (SULTs) 1A1 and 1A2 and their linkage disequilibrium in a Korean population and compare them with those of other ethnic groups. Methods: Genotypes of the SULT1A1*1,*2, and*3 and SULT1A2*1,*2, and*3 allelic variants were determined in 234 Korean subjects using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) methods. Results: Allele frequencies for SULT1A1*1 and*2 were 0.876 [95{\%} confidence interval (CI), 0.843-0.905] and 0.124 (95{\%} CI, 0.096-0.157), respectively. Similarly, those for SULT1A2*1 and*2 were 0.885 (95{\%} CI, 0.852-0.912) and 0.115 (95{\%} CI, 0.088-0.150), respectively. However, no subject with SULT1A1*3 or SULT1A2*3 was detected. These genotype distributions are similar to those of Asian populations including the Chinese and Japanese, but quite different from other ethnic groups such as African-Americans and Caucasians. The expected allelic frequencies of SULT1A1 and SULT1A2 at Hardy-Weinberg equilibrium are quite similar to the observed distributions in the population. SULT1A1*2 and SULT1A2*2, the most common variant alleles of these two genes, are strongly and positively linked in the Korean population (D ′ =0.8919, χ2 =343.24, P=0.0034). Conclusions: SULT1A1*2 and SULT1A2*2 are the major allelic variants in the Korean population, whereas the SULT1A1*3 and SULT1A2*3 alleles were not found. SULT1A1*2 and SULT1A2*2 are strongly linked.",
keywords = "Genetic polymorphism, Linkage disequilibrium, Sulfotransferase, SULT1A1, SULT1A2",
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T1 - Genetic polymorphisms and linkage disequilibrium of sulfotransferase SULT1A1 and SULT1A2 in a Korean population

T2 - Comparison of other ethnic groups

AU - Kim, Kyoung Ah

AU - Lee, Sook Young

AU - Park, Pil Whan

AU - Ha, Jong Myung

AU - Park, Ji-Young

PY - 2005/11/1

Y1 - 2005/11/1

N2 - Aims: To determine the allele frequencies of sulfotransferases (SULTs) 1A1 and 1A2 and their linkage disequilibrium in a Korean population and compare them with those of other ethnic groups. Methods: Genotypes of the SULT1A1*1,*2, and*3 and SULT1A2*1,*2, and*3 allelic variants were determined in 234 Korean subjects using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) methods. Results: Allele frequencies for SULT1A1*1 and*2 were 0.876 [95% confidence interval (CI), 0.843-0.905] and 0.124 (95% CI, 0.096-0.157), respectively. Similarly, those for SULT1A2*1 and*2 were 0.885 (95% CI, 0.852-0.912) and 0.115 (95% CI, 0.088-0.150), respectively. However, no subject with SULT1A1*3 or SULT1A2*3 was detected. These genotype distributions are similar to those of Asian populations including the Chinese and Japanese, but quite different from other ethnic groups such as African-Americans and Caucasians. The expected allelic frequencies of SULT1A1 and SULT1A2 at Hardy-Weinberg equilibrium are quite similar to the observed distributions in the population. SULT1A1*2 and SULT1A2*2, the most common variant alleles of these two genes, are strongly and positively linked in the Korean population (D ′ =0.8919, χ2 =343.24, P=0.0034). Conclusions: SULT1A1*2 and SULT1A2*2 are the major allelic variants in the Korean population, whereas the SULT1A1*3 and SULT1A2*3 alleles were not found. SULT1A1*2 and SULT1A2*2 are strongly linked.

AB - Aims: To determine the allele frequencies of sulfotransferases (SULTs) 1A1 and 1A2 and their linkage disequilibrium in a Korean population and compare them with those of other ethnic groups. Methods: Genotypes of the SULT1A1*1,*2, and*3 and SULT1A2*1,*2, and*3 allelic variants were determined in 234 Korean subjects using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) methods. Results: Allele frequencies for SULT1A1*1 and*2 were 0.876 [95% confidence interval (CI), 0.843-0.905] and 0.124 (95% CI, 0.096-0.157), respectively. Similarly, those for SULT1A2*1 and*2 were 0.885 (95% CI, 0.852-0.912) and 0.115 (95% CI, 0.088-0.150), respectively. However, no subject with SULT1A1*3 or SULT1A2*3 was detected. These genotype distributions are similar to those of Asian populations including the Chinese and Japanese, but quite different from other ethnic groups such as African-Americans and Caucasians. The expected allelic frequencies of SULT1A1 and SULT1A2 at Hardy-Weinberg equilibrium are quite similar to the observed distributions in the population. SULT1A1*2 and SULT1A2*2, the most common variant alleles of these two genes, are strongly and positively linked in the Korean population (D ′ =0.8919, χ2 =343.24, P=0.0034). Conclusions: SULT1A1*2 and SULT1A2*2 are the major allelic variants in the Korean population, whereas the SULT1A1*3 and SULT1A2*3 alleles were not found. SULT1A1*2 and SULT1A2*2 are strongly linked.

KW - Genetic polymorphism

KW - Linkage disequilibrium

KW - Sulfotransferase

KW - SULT1A1

KW - SULT1A2

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