Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism

Ihn Geun Choi, Baik Seok Kee, Hyun Gyun Son, Byung-Joo Ham, Byung Hwan Yang, Seok Hyeon Kim, Jun Suk Lee, Bong Ki Son, Byeong Yong Lee, Sang Yeol Lee, Young Gyu Chai, Hyoung Doo Shin

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol dependence (familial) and alcoholic patients without family history (non-familial). Genotype and allele frequencies of ALDH2 G1951A SNP in familial or non-familial alcoholic patients differ from normal controls. Neither 5-HTTLPR L/S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. These findings suggest that the genetic characteristics of alcohol metabolism in non-familial alcoholics fall between non-alcoholism and familial alcoholics.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalEuropean Neuropsychopharmacology
Volume16
Issue number2
DOIs
Publication statusPublished - 2006 Feb 1
Externally publishedYes

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Aldehyde Dehydrogenase
Dopamine Plasma Membrane Transport Proteins
Alcohol Dehydrogenase
Genetic Polymorphisms
Alcoholics
Alcoholism
Single Nucleotide Polymorphism
Genotype
Gene Frequency
Alleles
Alcohols

Keywords

  • Alcohol dehydrogenase 2
  • Alcoholism
  • Aldehyde dehydrogenase 2
  • Dopamine transporter
  • Family history
  • Serotonin transporter

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neurology
  • Pharmacology
  • Psychology(all)

Cite this

Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism. / Choi, Ihn Geun; Kee, Baik Seok; Son, Hyun Gyun; Ham, Byung-Joo; Yang, Byung Hwan; Kim, Seok Hyeon; Lee, Jun Suk; Son, Bong Ki; Lee, Byeong Yong; Lee, Sang Yeol; Chai, Young Gyu; Shin, Hyoung Doo.

In: European Neuropsychopharmacology, Vol. 16, No. 2, 01.02.2006, p. 123-128.

Research output: Contribution to journalArticle

Choi, Ihn Geun ; Kee, Baik Seok ; Son, Hyun Gyun ; Ham, Byung-Joo ; Yang, Byung Hwan ; Kim, Seok Hyeon ; Lee, Jun Suk ; Son, Bong Ki ; Lee, Byeong Yong ; Lee, Sang Yeol ; Chai, Young Gyu ; Shin, Hyoung Doo. / Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism. In: European Neuropsychopharmacology. 2006 ; Vol. 16, No. 2. pp. 123-128.
@article{f2eaaa55317448ffb71b796e05e7283c,
title = "Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism",
abstract = "One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol dependence (familial) and alcoholic patients without family history (non-familial). Genotype and allele frequencies of ALDH2 G1951A SNP in familial or non-familial alcoholic patients differ from normal controls. Neither 5-HTTLPR L/S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. These findings suggest that the genetic characteristics of alcohol metabolism in non-familial alcoholics fall between non-alcoholism and familial alcoholics.",
keywords = "Alcohol dehydrogenase 2, Alcoholism, Aldehyde dehydrogenase 2, Dopamine transporter, Family history, Serotonin transporter",
author = "Choi, {Ihn Geun} and Kee, {Baik Seok} and Son, {Hyun Gyun} and Byung-Joo Ham and Yang, {Byung Hwan} and Kim, {Seok Hyeon} and Lee, {Jun Suk} and Son, {Bong Ki} and Lee, {Byeong Yong} and Lee, {Sang Yeol} and Chai, {Young Gyu} and Shin, {Hyoung Doo}",
year = "2006",
month = "2",
day = "1",
doi = "10.1016/j.euroneuro.2005.07.006",
language = "English",
volume = "16",
pages = "123--128",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism

AU - Choi, Ihn Geun

AU - Kee, Baik Seok

AU - Son, Hyun Gyun

AU - Ham, Byung-Joo

AU - Yang, Byung Hwan

AU - Kim, Seok Hyeon

AU - Lee, Jun Suk

AU - Son, Bong Ki

AU - Lee, Byeong Yong

AU - Lee, Sang Yeol

AU - Chai, Young Gyu

AU - Shin, Hyoung Doo

PY - 2006/2/1

Y1 - 2006/2/1

N2 - One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol dependence (familial) and alcoholic patients without family history (non-familial). Genotype and allele frequencies of ALDH2 G1951A SNP in familial or non-familial alcoholic patients differ from normal controls. Neither 5-HTTLPR L/S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. These findings suggest that the genetic characteristics of alcohol metabolism in non-familial alcoholics fall between non-alcoholism and familial alcoholics.

AB - One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol dependence (familial) and alcoholic patients without family history (non-familial). Genotype and allele frequencies of ALDH2 G1951A SNP in familial or non-familial alcoholic patients differ from normal controls. Neither 5-HTTLPR L/S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. These findings suggest that the genetic characteristics of alcohol metabolism in non-familial alcoholics fall between non-alcoholism and familial alcoholics.

KW - Alcohol dehydrogenase 2

KW - Alcoholism

KW - Aldehyde dehydrogenase 2

KW - Dopamine transporter

KW - Family history

KW - Serotonin transporter

UR - http://www.scopus.com/inward/record.url?scp=31344454235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=31344454235&partnerID=8YFLogxK

U2 - 10.1016/j.euroneuro.2005.07.006

DO - 10.1016/j.euroneuro.2005.07.006

M3 - Article

VL - 16

SP - 123

EP - 128

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

IS - 2

ER -