Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism

Ihn Geun Choi, Baik Seok Kee, Hyun Gyun Son, Byung-Joo Ham, Byung Hwan Yang, Seok Hyeon Kim, Jun Suk Lee, Bong Ki Son, Byeong Yong Lee, Sang Yeol Lee, Young Gyu Chai, Hyoung Doo Shin

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol dependence (familial) and alcoholic patients without family history (non-familial). Genotype and allele frequencies of ALDH2 G1951A SNP in familial or non-familial alcoholic patients differ from normal controls. Neither 5-HTTLPR L/S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. These findings suggest that the genetic characteristics of alcohol metabolism in non-familial alcoholics fall between non-alcoholism and familial alcoholics.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalEuropean Neuropsychopharmacology
Volume16
Issue number2
DOIs
Publication statusPublished - 2006 Feb 1
Externally publishedYes

Keywords

  • Alcohol dehydrogenase 2
  • Alcoholism
  • Aldehyde dehydrogenase 2
  • Dopamine transporter
  • Family history
  • Serotonin transporter

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neurology
  • Pharmacology
  • Psychology(all)

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  • Cite this

    Choi, I. G., Kee, B. S., Son, H. G., Ham, B-J., Yang, B. H., Kim, S. H., Lee, J. S., Son, B. K., Lee, B. Y., Lee, S. Y., Chai, Y. G., & Shin, H. D. (2006). Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism. European Neuropsychopharmacology, 16(2), 123-128. https://doi.org/10.1016/j.euroneuro.2005.07.006