Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population

H. R. Han, H. J. Ryu, H. S. Cha, M. J. Go, Y. Ahn, B. K. Koo, Y. M. Cho, H. K. Lee, N. H. Cho, Chol Shin, H. D. Shin, K. Kimm, H. L. Kim, Bermseok Oh, Kyong Soo Park

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Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disorder that is characterized by insulin resistance and hyperglycemia. Leptin inhibits the glucose-stimulated insulin secretion, and leptin receptors are present on β cells as well as on fat cells, thus enabling leptin to modulate both insulin secretion and action. Therefore, leptin (LEP) and leptin receptor (LEPR) genes could play a role in the regulation of glucose and insulin after an oral glucose load. For the association study of LEP and LEPR with T2DM and metabolic traits, 752 women from Seoul National University Hospital (SNUH data) and 532 women from the Korean Health and Genome Study (KHGS data) were selected. Using the SNUH data, we identified that LEP-632G > A and + 4998A > C polymorphisms were marginally associated with T2DM, LEP+4950G > A was significantly associated with several metabolic traits, and LEPR+5193G > A, +7187A > C, +27265G > A, +35861T > C, and +52289A > G showed strongly significant association with body mass index (BMI). We observed reproducibility of these results using the KHGS data; LEP + 4950G > A and +4998A > C were significantly associated with systolic blood pressure and low-density lipoprotein cholesterol level, respectively. In conclusion, we observed that several polymorphisms in LEPR that had previous reports of association with BMI were significantly replicated in our samples and newly found that some variations of LEP were associated with T2DM and metabolic traits.

Original languageEnglish
Pages (from-to)105-115
Number of pages11
JournalClinical Genetics
Volume74
Issue number2
DOIs
Publication statusPublished - 2008 Aug 1

Fingerprint

Leptin Receptors
Leptin
Type 2 Diabetes Mellitus
Population
Genes
Glucose
Body Mass Index
Insulin
Blood Pressure
Insulin Receptor
Women's Health
Adipocytes
Reproducibility of Results
Hyperglycemia
LDL Cholesterol
Insulin Resistance
Genome

Keywords

  • BMI
  • LEP
  • LEPR
  • Metabolic trait
  • Replication
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population. / Han, H. R.; Ryu, H. J.; Cha, H. S.; Go, M. J.; Ahn, Y.; Koo, B. K.; Cho, Y. M.; Lee, H. K.; Cho, N. H.; Shin, Chol; Shin, H. D.; Kimm, K.; Kim, H. L.; Oh, Bermseok; Park, Kyong Soo.

In: Clinical Genetics, Vol. 74, No. 2, 01.08.2008, p. 105-115.

Research output: Contribution to journalArticle

Han, HR, Ryu, HJ, Cha, HS, Go, MJ, Ahn, Y, Koo, BK, Cho, YM, Lee, HK, Cho, NH, Shin, C, Shin, HD, Kimm, K, Kim, HL, Oh, B & Park, KS 2008, 'Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population', Clinical Genetics, vol. 74, no. 2, pp. 105-115. https://doi.org/10.1111/j.1399-0004.2008.01033.x
Han, H. R. ; Ryu, H. J. ; Cha, H. S. ; Go, M. J. ; Ahn, Y. ; Koo, B. K. ; Cho, Y. M. ; Lee, H. K. ; Cho, N. H. ; Shin, Chol ; Shin, H. D. ; Kimm, K. ; Kim, H. L. ; Oh, Bermseok ; Park, Kyong Soo. / Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population. In: Clinical Genetics. 2008 ; Vol. 74, No. 2. pp. 105-115.
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AU - Han, H. R.

AU - Ryu, H. J.

AU - Cha, H. S.

AU - Go, M. J.

AU - Ahn, Y.

AU - Koo, B. K.

AU - Cho, Y. M.

AU - Lee, H. K.

AU - Cho, N. H.

AU - Shin, Chol

AU - Shin, H. D.

AU - Kimm, K.

AU - Kim, H. L.

AU - Oh, Bermseok

AU - Park, Kyong Soo

PY - 2008/8/1

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N2 - Type 2 diabetes mellitus (T2DM) is a metabolic disorder that is characterized by insulin resistance and hyperglycemia. Leptin inhibits the glucose-stimulated insulin secretion, and leptin receptors are present on β cells as well as on fat cells, thus enabling leptin to modulate both insulin secretion and action. Therefore, leptin (LEP) and leptin receptor (LEPR) genes could play a role in the regulation of glucose and insulin after an oral glucose load. For the association study of LEP and LEPR with T2DM and metabolic traits, 752 women from Seoul National University Hospital (SNUH data) and 532 women from the Korean Health and Genome Study (KHGS data) were selected. Using the SNUH data, we identified that LEP-632G > A and + 4998A > C polymorphisms were marginally associated with T2DM, LEP+4950G > A was significantly associated with several metabolic traits, and LEPR+5193G > A, +7187A > C, +27265G > A, +35861T > C, and +52289A > G showed strongly significant association with body mass index (BMI). We observed reproducibility of these results using the KHGS data; LEP + 4950G > A and +4998A > C were significantly associated with systolic blood pressure and low-density lipoprotein cholesterol level, respectively. In conclusion, we observed that several polymorphisms in LEPR that had previous reports of association with BMI were significantly replicated in our samples and newly found that some variations of LEP were associated with T2DM and metabolic traits.

AB - Type 2 diabetes mellitus (T2DM) is a metabolic disorder that is characterized by insulin resistance and hyperglycemia. Leptin inhibits the glucose-stimulated insulin secretion, and leptin receptors are present on β cells as well as on fat cells, thus enabling leptin to modulate both insulin secretion and action. Therefore, leptin (LEP) and leptin receptor (LEPR) genes could play a role in the regulation of glucose and insulin after an oral glucose load. For the association study of LEP and LEPR with T2DM and metabolic traits, 752 women from Seoul National University Hospital (SNUH data) and 532 women from the Korean Health and Genome Study (KHGS data) were selected. Using the SNUH data, we identified that LEP-632G > A and + 4998A > C polymorphisms were marginally associated with T2DM, LEP+4950G > A was significantly associated with several metabolic traits, and LEPR+5193G > A, +7187A > C, +27265G > A, +35861T > C, and +52289A > G showed strongly significant association with body mass index (BMI). We observed reproducibility of these results using the KHGS data; LEP + 4950G > A and +4998A > C were significantly associated with systolic blood pressure and low-density lipoprotein cholesterol level, respectively. In conclusion, we observed that several polymorphisms in LEPR that had previous reports of association with BMI were significantly replicated in our samples and newly found that some variations of LEP were associated with T2DM and metabolic traits.

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KW - Replication

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