Genetics and epigenetics in allergic rhinitis

Bo Yoon Choi, Munsoo Han, Ji Won Kwak, Tae Hoon Kim

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

The pathogenesis of allergic rhinitis is associated with genetic, environmental, and epigenetic factors. Genotyping of single nucleotide polymorphisms (SNPs) is an advanced technique in the field of molecular genetics that is closely correlated with genome-wide association studies (GWASs) in large population groups with allergic diseases. Many recent studies have paid attention to the role of epigenetics, including alteration of DNA methylation, histone acetylation, and miRNA levels in the pathogenesis of allergic rhinitis. In this review article, genetics and epigenetics of allergic rhinitis, including information regarding functions and significance of previously known and newly-discovered genes, are summarized. Directions for future genetic and epigenetic studies of allergic rhinitis are also proposed.

Original languageEnglish
Article number2004
JournalGenes
Volume12
Issue number12
DOIs
Publication statusPublished - 2021 Dec

Keywords

  • Allergic rhinitis
  • Allergy
  • Asthma
  • Epigenetics
  • GWAS
  • Genetics

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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