Geno-Tox: Cell array biochip for genotoxicity monitoring and classification

Joo Myung Ahn, Man Bock Gu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In vitro genotoxicity tests detect carcinogens that are thought to act primarily via a mechanism involving direct genetic damage. In this study, we constructed a Geno-Tox cell array chip for genotoxicity testing; eight recombinant bioluminescent bacteria were used to successfully fabricate a Geno-Tox cell array chip. Four well-characterized DNA damage chemicals were selected to determine the capabilities of this Geno-Tox array chip, and each strain of the chip was distinctly responsive, according to the specific mode of genotoxic action. Therefore, this Geno-Tox cell array chip could be implemented to characterize and understand the genotoxic modes of impact; thus, it could be used to provide the genotoxic mechanism of action for new drugs or unknown or newly synthesized chemicals in food and the environment.

Original languageEnglish
Pages (from-to)752-760
Number of pages9
JournalApplied Biochemistry and Biotechnology
Volume168
Issue number4
DOIs
Publication statusPublished - 2012 Oct

Keywords

  • Bioluminescence bacteria
  • Cell array biochip
  • DNA damage response

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology

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