Genome-wide pathway analysis in attention-deficit/hyperactivity disorder

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This study aimed to (1) to identify candidate single-nucleotide polymorphisms (SNPs) and mechanisms of attention-deficit/hyperactivity disorder (ADHD) and (2) to generate SNP-to-gene-to-pathway hypotheses. An ADHD genome-wide association study (GWAS) dataset that included 428,074 SNPs in 924 trios (2,758 individuals) of European descent was used in this study. The Identify candidate Causal SNPs and Pathways (ICSNPathway) analysis was applied to the GWAS dataset. ICSNPathway analysis identified 11 candidate SNPs, 6 genes, and 6 pathways, which provided 6 hypothetical biological mechanisms. The strongest hypothetical biological mechanism was that rs2532502 alters the role of CD27 in the context of the pathways of positive regulation of nucleocytoplasmic transport [nominal p < 0.001; false discovery rate (FDR) = 0.028]. The second strongest mechanism was the rs1820204, rs1052571, rs1052576 → CASP9 → mitochondrial pathway (nominal p < 0.001; FDR = 0.032). The third mechanism was the rs1801516 → ATM → CD25 pathway (nominal p < 0.001; FDR = 0.034). By applying the ICSNPathway analysis to the ADHD GWAS data, 11 candidate SNPs, 6 genes that included CD27, CASP9, ATM, CD12orf65, OXER1, and ACRY, and 6 pathways were identified that may contribute to ADHD susceptibility.

Original languageEnglish
Pages (from-to)1189-1196
Number of pages8
JournalNeurological Sciences
Volume35
Issue number8
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Attention Deficit Disorder with Hyperactivity
Single Nucleotide Polymorphism
Genome
Genome-Wide Association Study
Genes
Cell Nucleus Active Transport

Keywords

  • Attention-deficit/hyperactivity disorder
  • Genome-wide association study
  • Pathway-based analysis

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Genome-wide pathway analysis in attention-deficit/hyperactivity disorder. / Lee, Young Ho; Song, Gwan Gyu.

In: Neurological Sciences, Vol. 35, No. 8, 01.01.2014, p. 1189-1196.

Research output: Contribution to journalArticle

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