Genomic copy number variations in the myelodysplastic syndrome and acute myeloid leukemia patients with del(5q) and/or -7/del(7q)

Rui Zhang, Young Mi Kim, Xianfu Wang, Yan Li, Xianglan Lu, Andrea R. Sternenberger, Shibo Li, Ji-Yun Lee

Research output: Contribution to journalArticle

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Abstract

The most common chromosomal abnormalities in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are -5/del(5q) and -7/del(7q). When -5/del(5q) and -7/del(7q) coexist in patients, a poor prognosis is typically associated. Given that -5/del(5q) and/or -7/del(7q) often are accompanied with additional recurrent chromosomal alterations, genetic change(s) on the accompanying chromosome(s) other than chromosomes 5 and 7 may be important factor(s) affecting leukemogenesis and disease prognosis. Using an integrated analysis of karyotype, FISH and array CGH results in this study, we evaluated the smallest region of overlap (SRO) of chromosomes 5 and 7 as well as copy number alterations (CNAs) on the other chromosomes. Moreover, the relationship between the CNAs and del(5q) and -7/del(7q) was investigated by categorizing the cases into three groups based on the abnormalities of chromosomes 5 and 7 [group I: cases only with del(5q), group II: cases only with -7/del(7q) and group III: concurrent del(5q) and del(7q) cases]. The overlapping SRO of chromosome 5 from groups I and III was 5q31.1-33.1 and of chromosome 7 from groups II and III was 7q31.31-q36.1. A total of 318 CNAs were observed; ~ 78.3% of them were identified on chromosomes other than chromosomes 5 and 7, which were defined as ‘other CNAs’. Group III was a distinctive group carrying the most high number (HN) CNAs, cryptic CNAs and ‘other CNAs’. The loss of TP53 was highly associated with del(5q). The loss of ETV6 was specifically associated with group III. These CNAs or genes may play a secondary role in disease progression and should be further evaluated for their clinical significance and influence on therapeutic approaches in patients with MDS/AML carrying del(5q) and/or -7/del(7q) in large-scale, patient population study.

Original languageEnglish
Pages (from-to)719-726
Number of pages8
JournalInternational Journal of Medical Sciences
Volume12
Issue number9
DOIs
Publication statusPublished - 2015 Aug 14

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Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 7
Myelodysplastic Syndromes
Acute Myeloid Leukemia
Chromosomes
Karyotype
Chromosome Aberrations
Disease Progression
Population
Genes

Keywords

  • -7/del(7q)
  • AML
  • Copy number alterations
  • del(5q)
  • MDS

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Genomic copy number variations in the myelodysplastic syndrome and acute myeloid leukemia patients with del(5q) and/or -7/del(7q). / Zhang, Rui; Kim, Young Mi; Wang, Xianfu; Li, Yan; Lu, Xianglan; Sternenberger, Andrea R.; Li, Shibo; Lee, Ji-Yun.

In: International Journal of Medical Sciences, Vol. 12, No. 9, 14.08.2015, p. 719-726.

Research output: Contribution to journalArticle

Zhang, Rui ; Kim, Young Mi ; Wang, Xianfu ; Li, Yan ; Lu, Xianglan ; Sternenberger, Andrea R. ; Li, Shibo ; Lee, Ji-Yun. / Genomic copy number variations in the myelodysplastic syndrome and acute myeloid leukemia patients with del(5q) and/or -7/del(7q). In: International Journal of Medical Sciences. 2015 ; Vol. 12, No. 9. pp. 719-726.
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AU - Lee, Ji-Yun

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