Genomic evolution of Vibrio cholerae

Yong Joon Cho, Hana Yi, Je Hee Lee, Dong Wook Kim, Jongsik Chun

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Vibrio cholera, the causal agent of cholera, also occupies an autochthonous aquatic inhabitant. The current, seventh cholera pandemic is linked to O1 El Tor biotype and O139 serogroups. In the last decades, we have witnessed a shift involving genetically and phenotypically varied pandemic clones in Asia and Africa. Recent comparative genomic studies have identified a large 'mobilome', or composed of mobile genomic islands in V. cholerae. All seventh pandemic isolates have highly related genome sequences, but they can be differentiated by set of these genomic islands. A consequence of the extensive lateral gene transfer is that classically important diagnostic markers, such as serotype and biotype, are not reliable and new methods based on genomic sequences are required.

Original languageEnglish
Pages (from-to)646-651
Number of pages6
JournalCurrent Opinion in Microbiology
Volume13
Issue number5
DOIs
Publication statusPublished - 2010 Oct 1
Externally publishedYes

Fingerprint

Vibrio cholerae
Pandemics
Genomic Islands
Cholera
Horizontal Gene Transfer
Clone Cells
Genome
Serogroup

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

Cite this

Genomic evolution of Vibrio cholerae. / Cho, Yong Joon; Yi, Hana; Lee, Je Hee; Kim, Dong Wook; Chun, Jongsik.

In: Current Opinion in Microbiology, Vol. 13, No. 5, 01.10.2010, p. 646-651.

Research output: Contribution to journalArticle

Cho, YJ, Yi, H, Lee, JH, Kim, DW & Chun, J 2010, 'Genomic evolution of Vibrio cholerae', Current Opinion in Microbiology, vol. 13, no. 5, pp. 646-651. https://doi.org/10.1016/j.mib.2010.08.007
Cho, Yong Joon ; Yi, Hana ; Lee, Je Hee ; Kim, Dong Wook ; Chun, Jongsik. / Genomic evolution of Vibrio cholerae. In: Current Opinion in Microbiology. 2010 ; Vol. 13, No. 5. pp. 646-651.
@article{1b3074ad9bbb489e9a80f270522e2596,
title = "Genomic evolution of Vibrio cholerae",
abstract = "Vibrio cholera, the causal agent of cholera, also occupies an autochthonous aquatic inhabitant. The current, seventh cholera pandemic is linked to O1 El Tor biotype and O139 serogroups. In the last decades, we have witnessed a shift involving genetically and phenotypically varied pandemic clones in Asia and Africa. Recent comparative genomic studies have identified a large 'mobilome', or composed of mobile genomic islands in V. cholerae. All seventh pandemic isolates have highly related genome sequences, but they can be differentiated by set of these genomic islands. A consequence of the extensive lateral gene transfer is that classically important diagnostic markers, such as serotype and biotype, are not reliable and new methods based on genomic sequences are required.",
author = "Cho, {Yong Joon} and Hana Yi and Lee, {Je Hee} and Kim, {Dong Wook} and Jongsik Chun",
year = "2010",
month = "10",
day = "1",
doi = "10.1016/j.mib.2010.08.007",
language = "English",
volume = "13",
pages = "646--651",
journal = "Current Opinion in Microbiology",
issn = "1369-5274",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Genomic evolution of Vibrio cholerae

AU - Cho, Yong Joon

AU - Yi, Hana

AU - Lee, Je Hee

AU - Kim, Dong Wook

AU - Chun, Jongsik

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Vibrio cholera, the causal agent of cholera, also occupies an autochthonous aquatic inhabitant. The current, seventh cholera pandemic is linked to O1 El Tor biotype and O139 serogroups. In the last decades, we have witnessed a shift involving genetically and phenotypically varied pandemic clones in Asia and Africa. Recent comparative genomic studies have identified a large 'mobilome', or composed of mobile genomic islands in V. cholerae. All seventh pandemic isolates have highly related genome sequences, but they can be differentiated by set of these genomic islands. A consequence of the extensive lateral gene transfer is that classically important diagnostic markers, such as serotype and biotype, are not reliable and new methods based on genomic sequences are required.

AB - Vibrio cholera, the causal agent of cholera, also occupies an autochthonous aquatic inhabitant. The current, seventh cholera pandemic is linked to O1 El Tor biotype and O139 serogroups. In the last decades, we have witnessed a shift involving genetically and phenotypically varied pandemic clones in Asia and Africa. Recent comparative genomic studies have identified a large 'mobilome', or composed of mobile genomic islands in V. cholerae. All seventh pandemic isolates have highly related genome sequences, but they can be differentiated by set of these genomic islands. A consequence of the extensive lateral gene transfer is that classically important diagnostic markers, such as serotype and biotype, are not reliable and new methods based on genomic sequences are required.

UR - http://www.scopus.com/inward/record.url?scp=77957759165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957759165&partnerID=8YFLogxK

U2 - 10.1016/j.mib.2010.08.007

DO - 10.1016/j.mib.2010.08.007

M3 - Article

C2 - 20851041

AN - SCOPUS:77957759165

VL - 13

SP - 646

EP - 651

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

SN - 1369-5274

IS - 5

ER -