Genomic evolution of Vibrio cholerae

Yong Joon Cho, Hana Yi, Je Hee Lee, Dong Wook Kim, Jongsik Chun

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Vibrio cholera, the causal agent of cholera, also occupies an autochthonous aquatic inhabitant. The current, seventh cholera pandemic is linked to O1 El Tor biotype and O139 serogroups. In the last decades, we have witnessed a shift involving genetically and phenotypically varied pandemic clones in Asia and Africa. Recent comparative genomic studies have identified a large 'mobilome', or composed of mobile genomic islands in V. cholerae. All seventh pandemic isolates have highly related genome sequences, but they can be differentiated by set of these genomic islands. A consequence of the extensive lateral gene transfer is that classically important diagnostic markers, such as serotype and biotype, are not reliable and new methods based on genomic sequences are required.

Original languageEnglish
Pages (from-to)646-651
Number of pages6
JournalCurrent Opinion in Microbiology
Volume13
Issue number5
DOIs
Publication statusPublished - 2010 Oct
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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