Genomic imbalances in Korean hepatocellular carcinoma

Gi Jin Kim, Seong Jin Cho, Nam Hee Won, Jin Mo Sung, Hyun Kim, Yong Hyuck Chun, Sun-Hwa Park

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is one of the most prevalent gastrointestinal malignant tumors in Southeast Asia. Thirty-one cirrhotic HCC, 14 noncirrhotic HCC, and 13 metastastic HCC in the Korean population were investigated on microdissected tissues for chromosomal aberrations by degenerate oligonucleotide-primed polymerase chain reaction (PCR) comparative genomic hybridization. A number of prominent sites of genomic imbalances were observed. The gains of 1q, 6p, 7, 8q, 12q, 13q31∼q32, 16p, 17q, and 20q and the losses of 1p, 4q, 6q, 8p, 9p, and 13q regions were observed with a similar high frequency in all types. Various chromosomal aberrations were observed preferentially to specific types. Gains of 4p15∼pter, 10q24∼qter, 18p11∼pter, and 19p10∼pter and a loss of 11q14∼q22 were observed in the cirrhotic HCC, whereas losses of 14q21∼q23 and 10q22∼q23 were observed in noncirrhotic HCC. In metastatic HCC, gains of 3q25∼qter and Xp21∼pter and losses of 21q11∼qter and Y were observed. The recurrent gains and losses of chromosomal regions identified in this study are consistent with several previous observations and provide possible candidate regions for the involvement of tumorigenesis and progressions of HCC.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume142
Issue number2
DOIs
Publication statusPublished - 2003 Apr 15

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Hepatocellular Carcinoma
Chromosome Aberrations
Southeastern Asia
Comparative Genomic Hybridization
Carcinogenesis
Polymerase Chain Reaction
Population
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Genomic imbalances in Korean hepatocellular carcinoma. / Kim, Gi Jin; Cho, Seong Jin; Won, Nam Hee; Sung, Jin Mo; Kim, Hyun; Chun, Yong Hyuck; Park, Sun-Hwa.

In: Cancer Genetics and Cytogenetics, Vol. 142, No. 2, 15.04.2003, p. 129-133.

Research output: Contribution to journalArticle

Kim, Gi Jin ; Cho, Seong Jin ; Won, Nam Hee ; Sung, Jin Mo ; Kim, Hyun ; Chun, Yong Hyuck ; Park, Sun-Hwa. / Genomic imbalances in Korean hepatocellular carcinoma. In: Cancer Genetics and Cytogenetics. 2003 ; Vol. 142, No. 2. pp. 129-133.
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