Gentamicin-releasing urethral catheter for short-term catheterization

Yong Woo Cho, Jae Hyung Park, Sang Hee Kim, Yong Hyun Cho, Joong Myung Choi, Hee Jong Shin, You Han Bae, Hesson Chung, Seo Young Jeong, Ick Chan Kwon

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Urethral catheters, widely used for the drainage of the bladder, are associated with most urinary tract infections (UTIs) that account for 40% of all episodes occurring in acute-care hospitals. This study aimed to develop a gentamicin-releasing catheter that effectively prevents UTIs for short-term catheterization. For physical loading of gentamicin, the urethral catheters were coated by the simple dipping method with poly(ethylene-co-vinyl acetate) (EVA) and EVA/poly(ethylene oxide) (PEO) blends containing gentamicin. By varying the molecular weight (MW) and contents of PEO in the blends, various catheter surfaces were produced. In vitro drug release studies demonstrated that all the coated catheters exhibited sustained release up to 7 days; however, the release pattern was significantly dependant on the coating layers. Of the coated catheters, EVA/PEO (MW = 100k)-coated catheters were utilized to evaluate the antibacterial activity using an inhibition zone test, since they showed a promising drug release behavior and had PEO-rich biocompatible surfaces. In accordance with drug release behavior, EVA/PEO-coated catheters exhibited antibacterial activities for 7 days against Proteus vulgaris, Staphylococcus aureus and Staphylococcus epidermidis. These results imply that the catheters coated with EVA/PEO have a potential for short-term catheterization.

Original languageEnglish
Pages (from-to)963-972
Number of pages10
JournalJournal of Biomaterials Science, Polymer Edition
Volume14
Issue number9
DOIs
Publication statusPublished - 2003 Nov 14
Externally publishedYes

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Keywords

  • Antibacterial activity
  • Catheter coating
  • EVA
  • Gentamicin
  • PEO
  • Urethral catheter

ASJC Scopus subject areas

  • Biophysics

Cite this

Cho, Y. W., Park, J. H., Kim, S. H., Cho, Y. H., Choi, J. M., Shin, H. J., Bae, Y. H., Chung, H., Jeong, S. Y., & Kwon, I. C. (2003). Gentamicin-releasing urethral catheter for short-term catheterization. Journal of Biomaterials Science, Polymer Edition, 14(9), 963-972. https://doi.org/10.1163/156856203322381447