Gentisyl alcohol inhibits proliferation and induces apoptosis via mitochondrial dysfunction and regulation of MAPK and PI3K/AKT pathways in epithelial ovarian cancer cells

Jiyeon Ham, Whasun Lim, Kyeongwon Kim, Young Mok Heo, Seung Mok Ryu, Dongho Lee, Jae Jin Kim, Gwonhwa Song

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Ovarian cancer is one of the prevalent gynecological cancers occurring in women. In particular, the efficiency of standard therapeutic methods decreases when recurrence and chemoresistance ensue. To assist standard anti-cancer agents in the cure of ovarian cancer, development and application of new compounds such as small molecules or natural products are required. Gentisyl alcohol is one of the secondary metabolites that can be obtained by purification from bacteria or fungi and is known to have antibacterial, antifungal, antiviral, and anti-cancer effects. In the present study, we verified the effect of gentisyl alcohol derived from marine Arthrinium sp. on suppressing proliferation and inducing apoptosis via DNA fragmentation in human ovarian cancers cells (ES2 and OV90 cells). We also confirmed that there was an accumulation of sub-G1 cells and a loss of mitochondrial membrane potential with calcium dysregulation in gentisyl alcohol-treated ovarian cancer cells. Moreover, gentisyl alcohol up-regulated signal transduction of MAPK and PI3K/AKT pathways. Collectively, our results demonstrated the possibility of gentisyl alcohol as a novel therapeutic agent for human ovarian cancer.

Original languageEnglish
Article number331
JournalMarine drugs
Volume17
Issue number6
DOIs
Publication statusPublished - 2019 Jun 3

Keywords

  • Calcium dysregulation
  • Gentisyl alcohol
  • Mitochondrial dysfunction
  • Ovarian cancer

ASJC Scopus subject areas

  • Drug Discovery

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