Abstract
Enzymatic biosensor reactions follow the Michaelis-Menten kinetics, coupled with diffusion. The diffusion reaction processes for amperometric enzyme biosensors have been simulated to explore the geometrical effects of nanowire array electrodes (NWAEs) and nanowire array stack electrodes (NWASEs) from the viewpoint of enhanced mass transport and increased reaction surface area in two limiting cases. For practical analysis considering sensor fabrication, most samples are assumed to have the same unit square (1 cm × 1 cm) footprint. In the reaction-controlled case, the surface area increment improves the sensitivity regardless of electrode geometry. However, in the diffusion-controlled case, well-controlled NWAE or NWASE geometries as well as the increased surface area improve the sensitivity when the peak current at an early stage of the reaction is measured. Peak current engineering by adjusting the geometric parameters of NWAEs and NWASEs will result in a highly sensitive amperometric enzyme biosensor in the diffusion-controlled case. In contrast to previous micro- and nanoelectrode array studies, we investigated NWASEs representing entangled nanowire network electrodes, and report significant improvements in both limiting cases.
| Original language | English |
|---|---|
| Pages (from-to) | 222-229 |
| Number of pages | 8 |
| Journal | Sensors and Actuators, B: Chemical |
| Volume | 183 |
| DOIs | |
| Publication status | Published - 2013 May 3 |
Fingerprint
Keywords
- Amperometric enzyme biosensor Nanowire array electrode Nanowire array stack electrode Geometry Mass transport Surface area
ASJC Scopus subject areas
- Instrumentation
- Materials Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Electrical and Electronic Engineering
Cite this
Geometrical effects of nanowire electrodes for amperometric enzyme biosensors. / Kim, Sangwook; Na, Junhong; Lee, Seung Koo; Song, Min Jung; Kang, Pilsoo; Huh, Junghwan; Lim, Dae-Soon; Kim, Gyu-Tae.
In: Sensors and Actuators, B: Chemical, Vol. 183, 03.05.2013, p. 222-229.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Geometrical effects of nanowire electrodes for amperometric enzyme biosensors
AU - Kim, Sangwook
AU - Na, Junhong
AU - Lee, Seung Koo
AU - Song, Min Jung
AU - Kang, Pilsoo
AU - Huh, Junghwan
AU - Lim, Dae-Soon
AU - Kim, Gyu-Tae
PY - 2013/5/3
Y1 - 2013/5/3
N2 - Enzymatic biosensor reactions follow the Michaelis-Menten kinetics, coupled with diffusion. The diffusion reaction processes for amperometric enzyme biosensors have been simulated to explore the geometrical effects of nanowire array electrodes (NWAEs) and nanowire array stack electrodes (NWASEs) from the viewpoint of enhanced mass transport and increased reaction surface area in two limiting cases. For practical analysis considering sensor fabrication, most samples are assumed to have the same unit square (1 cm × 1 cm) footprint. In the reaction-controlled case, the surface area increment improves the sensitivity regardless of electrode geometry. However, in the diffusion-controlled case, well-controlled NWAE or NWASE geometries as well as the increased surface area improve the sensitivity when the peak current at an early stage of the reaction is measured. Peak current engineering by adjusting the geometric parameters of NWAEs and NWASEs will result in a highly sensitive amperometric enzyme biosensor in the diffusion-controlled case. In contrast to previous micro- and nanoelectrode array studies, we investigated NWASEs representing entangled nanowire network electrodes, and report significant improvements in both limiting cases.
AB - Enzymatic biosensor reactions follow the Michaelis-Menten kinetics, coupled with diffusion. The diffusion reaction processes for amperometric enzyme biosensors have been simulated to explore the geometrical effects of nanowire array electrodes (NWAEs) and nanowire array stack electrodes (NWASEs) from the viewpoint of enhanced mass transport and increased reaction surface area in two limiting cases. For practical analysis considering sensor fabrication, most samples are assumed to have the same unit square (1 cm × 1 cm) footprint. In the reaction-controlled case, the surface area increment improves the sensitivity regardless of electrode geometry. However, in the diffusion-controlled case, well-controlled NWAE or NWASE geometries as well as the increased surface area improve the sensitivity when the peak current at an early stage of the reaction is measured. Peak current engineering by adjusting the geometric parameters of NWAEs and NWASEs will result in a highly sensitive amperometric enzyme biosensor in the diffusion-controlled case. In contrast to previous micro- and nanoelectrode array studies, we investigated NWASEs representing entangled nanowire network electrodes, and report significant improvements in both limiting cases.
KW - Amperometric enzyme biosensor Nanowire array electrode Nanowire array stack electrode Geometry Mass transport Surface area
UR - http://www.scopus.com/inward/record.url?scp=84876840787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876840787&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2013.03.095
DO - 10.1016/j.snb.2013.03.095
M3 - Article
AN - SCOPUS:84876840787
VL - 183
SP - 222
EP - 229
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
SN - 0925-4005
ER -