TY - JOUR
T1 - Geometrical effects of nanowire electrodes for amperometric enzyme biosensors
AU - Kim, Sangwook
AU - Na, Junhong
AU - Lee, Seung Koo
AU - Song, Min Jung
AU - Kang, Pilsoo
AU - Huh, Junghwan
AU - Lim, Dae Soon
AU - Kim, Gyu Tae
N1 - Funding Information:
We thankfully acknowledge the financial support from the Ministry of Education, Science and Technology, provided to the project EDISON (EDucation-research Integration through Simulation On the Net, Grant No.: 2012035308). This study was also supported by Korea University Grant . The authors would like to thank Ho-Kyun Jang for 3D graphics, and Sung-Hee Lee for secretarial support.
PY - 2013
Y1 - 2013
N2 - Enzymatic biosensor reactions follow the Michaelis-Menten kinetics, coupled with diffusion. The diffusion reaction processes for amperometric enzyme biosensors have been simulated to explore the geometrical effects of nanowire array electrodes (NWAEs) and nanowire array stack electrodes (NWASEs) from the viewpoint of enhanced mass transport and increased reaction surface area in two limiting cases. For practical analysis considering sensor fabrication, most samples are assumed to have the same unit square (1 cm × 1 cm) footprint. In the reaction-controlled case, the surface area increment improves the sensitivity regardless of electrode geometry. However, in the diffusion-controlled case, well-controlled NWAE or NWASE geometries as well as the increased surface area improve the sensitivity when the peak current at an early stage of the reaction is measured. Peak current engineering by adjusting the geometric parameters of NWAEs and NWASEs will result in a highly sensitive amperometric enzyme biosensor in the diffusion-controlled case. In contrast to previous micro- and nanoelectrode array studies, we investigated NWASEs representing entangled nanowire network electrodes, and report significant improvements in both limiting cases.
AB - Enzymatic biosensor reactions follow the Michaelis-Menten kinetics, coupled with diffusion. The diffusion reaction processes for amperometric enzyme biosensors have been simulated to explore the geometrical effects of nanowire array electrodes (NWAEs) and nanowire array stack electrodes (NWASEs) from the viewpoint of enhanced mass transport and increased reaction surface area in two limiting cases. For practical analysis considering sensor fabrication, most samples are assumed to have the same unit square (1 cm × 1 cm) footprint. In the reaction-controlled case, the surface area increment improves the sensitivity regardless of electrode geometry. However, in the diffusion-controlled case, well-controlled NWAE or NWASE geometries as well as the increased surface area improve the sensitivity when the peak current at an early stage of the reaction is measured. Peak current engineering by adjusting the geometric parameters of NWAEs and NWASEs will result in a highly sensitive amperometric enzyme biosensor in the diffusion-controlled case. In contrast to previous micro- and nanoelectrode array studies, we investigated NWASEs representing entangled nanowire network electrodes, and report significant improvements in both limiting cases.
KW - Amperometric enzyme biosensor Nanowire array electrode Nanowire array stack electrode Geometry Mass transport Surface area
UR - http://www.scopus.com/inward/record.url?scp=84876840787&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2013.03.095
DO - 10.1016/j.snb.2013.03.095
M3 - Article
AN - SCOPUS:84876840787
VL - 183
SP - 222
EP - 229
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
SN - 0925-4005
ER -