Geometrical effects of nanowire electrodes for amperometric enzyme biosensors

Sangwook Kim, Junhong Na, Seung Koo Lee, Min Jung Song, Pilsoo Kang, Junghwan Huh, Dae-Soon Lim, Gyu-Tae Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Enzymatic biosensor reactions follow the Michaelis-Menten kinetics, coupled with diffusion. The diffusion reaction processes for amperometric enzyme biosensors have been simulated to explore the geometrical effects of nanowire array electrodes (NWAEs) and nanowire array stack electrodes (NWASEs) from the viewpoint of enhanced mass transport and increased reaction surface area in two limiting cases. For practical analysis considering sensor fabrication, most samples are assumed to have the same unit square (1 cm × 1 cm) footprint. In the reaction-controlled case, the surface area increment improves the sensitivity regardless of electrode geometry. However, in the diffusion-controlled case, well-controlled NWAE or NWASE geometries as well as the increased surface area improve the sensitivity when the peak current at an early stage of the reaction is measured. Peak current engineering by adjusting the geometric parameters of NWAEs and NWASEs will result in a highly sensitive amperometric enzyme biosensor in the diffusion-controlled case. In contrast to previous micro- and nanoelectrode array studies, we investigated NWASEs representing entangled nanowire network electrodes, and report significant improvements in both limiting cases.

Original languageEnglish
Pages (from-to)222-229
Number of pages8
JournalSensors and Actuators, B: Chemical
Volume183
DOIs
Publication statusPublished - 2013 May 3

Fingerprint

bioinstrumentation
Biosensors
Nanowires
enzymes
nanowires
Enzymes
Electrodes
electrodes
Geometry
Microelectrodes
sensitivity
Surface reactions
footprints
geometry
surface reactions
Mass transfer
adjusting
engineering
Fabrication
fabrication

Keywords

  • Amperometric enzyme biosensor Nanowire array electrode Nanowire array stack electrode Geometry Mass transport Surface area

ASJC Scopus subject areas

  • Instrumentation
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

Cite this

Geometrical effects of nanowire electrodes for amperometric enzyme biosensors. / Kim, Sangwook; Na, Junhong; Lee, Seung Koo; Song, Min Jung; Kang, Pilsoo; Huh, Junghwan; Lim, Dae-Soon; Kim, Gyu-Tae.

In: Sensors and Actuators, B: Chemical, Vol. 183, 03.05.2013, p. 222-229.

Research output: Contribution to journalArticle

Kim, Sangwook ; Na, Junhong ; Lee, Seung Koo ; Song, Min Jung ; Kang, Pilsoo ; Huh, Junghwan ; Lim, Dae-Soon ; Kim, Gyu-Tae. / Geometrical effects of nanowire electrodes for amperometric enzyme biosensors. In: Sensors and Actuators, B: Chemical. 2013 ; Vol. 183. pp. 222-229.
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