Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production

Qinghao Jin, Chul Lee, Jin Woo Lee, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Jin Sook Kim, Joo Hwan Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC<inf>50</inf> values ranging 1.48 to 16.66 μM.

Original languageEnglish
Pages (from-to)384-387
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume63
Issue number5
Publication statusPublished - 2015 May 1

Fingerprint

Flavanones
Fractionation
Inhibitory Concentration 50
Lipopolysaccharides
Nitric Oxide
Nuclear magnetic resonance
flavanone

Keywords

  • Geranylated flavanone
  • Nitric oxide inhibitor
  • Paulownia coreana
  • Paulowniaceae

ASJC Scopus subject areas

  • Drug Discovery
  • Chemistry(all)

Cite this

Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production. / Jin, Qinghao; Lee, Chul; Lee, Jin Woo; Lee, Dongho; Kim, Youngsoo; Hong, Jin Tae; Kim, Jin Sook; Kim, Joo Hwan; Lee, Mi Kyeong; Hwang, Bang Yeon.

In: Chemical and Pharmaceutical Bulletin, Vol. 63, No. 5, 01.05.2015, p. 384-387.

Research output: Contribution to journalArticle

Jin, Q, Lee, C, Lee, JW, Lee, D, Kim, Y, Hong, JT, Kim, JS, Kim, JH, Lee, MK & Hwang, BY 2015, 'Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production', Chemical and Pharmaceutical Bulletin, vol. 63, no. 5, pp. 384-387.
Jin, Qinghao ; Lee, Chul ; Lee, Jin Woo ; Lee, Dongho ; Kim, Youngsoo ; Hong, Jin Tae ; Kim, Jin Sook ; Kim, Joo Hwan ; Lee, Mi Kyeong ; Hwang, Bang Yeon. / Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production. In: Chemical and Pharmaceutical Bulletin. 2015 ; Vol. 63, No. 5. pp. 384-387.
@article{2eac2f04af3d450f8c61ebb6c788c698,
title = "Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production",
abstract = "The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 μM.",
keywords = "Geranylated flavanone, Nitric oxide inhibitor, Paulownia coreana, Paulowniaceae",
author = "Qinghao Jin and Chul Lee and Lee, {Jin Woo} and Dongho Lee and Youngsoo Kim and Hong, {Jin Tae} and Kim, {Jin Sook} and Kim, {Joo Hwan} and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",
year = "2015",
month = "5",
day = "1",
language = "English",
volume = "63",
pages = "384--387",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "Pharmaceutical Society of Japan",
number = "5",

}

TY - JOUR

T1 - Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production

AU - Jin, Qinghao

AU - Lee, Chul

AU - Lee, Jin Woo

AU - Lee, Dongho

AU - Kim, Youngsoo

AU - Hong, Jin Tae

AU - Kim, Jin Sook

AU - Kim, Joo Hwan

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

PY - 2015/5/1

Y1 - 2015/5/1

N2 - The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 μM.

AB - The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 μM.

KW - Geranylated flavanone

KW - Nitric oxide inhibitor

KW - Paulownia coreana

KW - Paulowniaceae

UR - http://www.scopus.com/inward/record.url?scp=84929994611&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929994611&partnerID=8YFLogxK

M3 - Article

C2 - 25948332

AN - SCOPUS:84929994611

VL - 63

SP - 384

EP - 387

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 5

ER -