Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production

Qinghao Jin, Chul Lee, Jin Woo Lee, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Jin Sook Kim, Joo Hwan Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC<inf>50</inf> values ranging 1.48 to 16.66 μM.

Original languageEnglish
Pages (from-to)384-387
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume63
Issue number5
Publication statusPublished - 2015 May 1

Keywords

  • Geranylated flavanone
  • Nitric oxide inhibitor
  • Paulownia coreana
  • Paulowniaceae

ASJC Scopus subject areas

  • Drug Discovery
  • Chemistry(all)

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  • Cite this

    Jin, Q., Lee, C., Lee, J. W., Lee, D., Kim, Y., Hong, J. T., Kim, J. S., Kim, J. H., Lee, M. K., & Hwang, B. Y. (2015). Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production. Chemical and Pharmaceutical Bulletin, 63(5), 384-387.