GFP-expressing influenza a virus for evaluation of the efficacy of antiviral agents

Jin Il Kim, Sehee Park, Ilseob Lee, Sangmoo Lee, Saem Shin, Yongkwan Won, Min Woong Hwang, Joon Yong Bae, Jun Heo, Hye Eun Hyun, Hyejin Jun, Soon Sung Lim, Man Seong Park

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

To address its value as a screening tool in the development of antiviral drugs, a recombinant influenza virus expressing green fluorescent protein (rPR8-GFP virus) was investigated in vitro and in vivo. The inhibition of viral growth by a neuraminidase inhibitor in the cells or lower respiratory tracts of mice could be visualized by the level of fluorescence. In addition, the rPR8-GFP virus exhibited high pathogenicity in mice. Taken together, these results suggest that the rPR8-GFP virus can be a useful tool for the rapid identification of antiviral drugs active against influenza viruses.

Original languageEnglish
Pages (from-to)359-362
Number of pages4
JournalJournal of Microbiology
Volume50
Issue number2
DOIs
Publication statusPublished - 2012 Apr
Externally publishedYes

Keywords

  • antiviral drug
  • green fluorescent protein
  • influenza

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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