Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats

Soojung Oh, Mak Soon Lee, Sunyoon Jung, Seunghae Kim, Hyeyoung Park, Seonyoung Park, Seog Young Kim, Chong Tai Kim, Young Hee Jo, In-Hwan Kim, Yangha Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Mitochondrial dysfunction and dyslipidemia are associated with obesity-linked metabolic disorders. The aim of this study was to investigate the effects of ginger extract on muscle mitochondrial biogenesis and high-density lipoprotein-cholesterol (HDL-C) metabolism in high-fat diet-fed rats. Supplementation with ginger extract reduced final body weight and epididymal adipose tissue mass without affecting energy intake (p < 0.05). Ginger extract increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as key genes expression related to mitochondrial biogenesis, including peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear respiratory factor-1 (NRF-1) and transcription factor A (Tfam) in skeletal muscle (p < 0.05). In addition, ginger extract elevated serum HDL-C along with up-regulating ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA-1) and lecithin-cholesterol acyltransferase (LCAT) mRNA in liver (p < 0.05). These results suggest that ginger extract may have a beneficial effect against obesity-related metabolic disorders with elevating muscle mitochondrial biogenesis and serum HDL-C level.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalJournal of Functional Foods
Volume29
DOIs
Publication statusPublished - 2017 Feb 1

Keywords

  • Ginger
  • HDL cholesterol
  • Metabolic disorder
  • Muscle mitochondrial biogenesis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats'. Together they form a unique fingerprint.

  • Cite this

    Oh, S., Lee, M. S., Jung, S., Kim, S., Park, H., Park, S., Kim, S. Y., Kim, C. T., Jo, Y. H., Kim, I-H., & Kim, Y. (2017). Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats. Journal of Functional Foods, 29, 193-200. https://doi.org/10.1016/j.jff.2016.12.023