Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats

Soojung Oh, Mak Soon Lee, Sunyoon Jung, Seunghae Kim, Hyeyoung Park, Seonyoung Park, Seog Young Kim, Chong Tai Kim, Young Hee Jo, In-Hwan Kim, Yangha Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Mitochondrial dysfunction and dyslipidemia are associated with obesity-linked metabolic disorders. The aim of this study was to investigate the effects of ginger extract on muscle mitochondrial biogenesis and high-density lipoprotein-cholesterol (HDL-C) metabolism in high-fat diet-fed rats. Supplementation with ginger extract reduced final body weight and epididymal adipose tissue mass without affecting energy intake (p < 0.05). Ginger extract increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as key genes expression related to mitochondrial biogenesis, including peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear respiratory factor-1 (NRF-1) and transcription factor A (Tfam) in skeletal muscle (p < 0.05). In addition, ginger extract elevated serum HDL-C along with up-regulating ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA-1) and lecithin-cholesterol acyltransferase (LCAT) mRNA in liver (p < 0.05). These results suggest that ginger extract may have a beneficial effect against obesity-related metabolic disorders with elevating muscle mitochondrial biogenesis and serum HDL-C level.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalJournal of Functional Foods
Volume29
DOIs
Publication statusPublished - 2017 Feb 1

Fingerprint

Ginger
ginger
High Fat Diet
Organelle Biogenesis
high fat diet
high density lipoprotein cholesterol
HDL Cholesterol
Muscles
muscles
rats
extracts
Serum
metabolic diseases
Nuclear Respiratory Factor 1
obesity
Obesity
apolipoprotein A
phosphatidylcholine-choline acyltransferase
Mitochondrial Size
Phosphatidylcholine-Sterol O-Acyltransferase

Keywords

  • Ginger
  • HDL cholesterol
  • Metabolic disorder
  • Muscle mitochondrial biogenesis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Nutrition and Dietetics

Cite this

Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats. / Oh, Soojung; Lee, Mak Soon; Jung, Sunyoon; Kim, Seunghae; Park, Hyeyoung; Park, Seonyoung; Kim, Seog Young; Kim, Chong Tai; Jo, Young Hee; Kim, In-Hwan; Kim, Yangha.

In: Journal of Functional Foods, Vol. 29, 01.02.2017, p. 193-200.

Research output: Contribution to journalArticle

Oh, Soojung ; Lee, Mak Soon ; Jung, Sunyoon ; Kim, Seunghae ; Park, Hyeyoung ; Park, Seonyoung ; Kim, Seog Young ; Kim, Chong Tai ; Jo, Young Hee ; Kim, In-Hwan ; Kim, Yangha. / Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats. In: Journal of Functional Foods. 2017 ; Vol. 29. pp. 193-200.
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