Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2

Tao Yu, Yanyan Yang, Yi Seong Kwak, Gwan Gyu Song, Mi Yeon Kim, Man Hee Rhee, Jae Youl Cho

    Research output: Contribution to journalArticlepeer-review

    62 Citations (Scopus)

    Abstract

    Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, antiinflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects. Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-a/interferon-g-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation. Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-a and interleukin-1b. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling.

    Original languageEnglish
    Pages (from-to)127-133
    Number of pages7
    JournalJournal of Ginseng Research
    Volume41
    Issue number2
    DOIs
    Publication statusPublished - 2017 Apr 1

    Keywords

    • Anti-inflammatory activity
    • Ginsenoside Rc
    • P38
    • Panax ginseng
    • TANK-binding kinase 1

    ASJC Scopus subject areas

    • Biotechnology
    • Biochemistry, Genetics and Molecular Biology (miscellaneous)
    • Complementary and alternative medicine

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