Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2

Tao Yu, Yanyan Yang, Yi Seong Kwak, Gwan Gyu Song, Mi Yeon Kim, Man Hee Rhee, Jae Youl Cho

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, antiinflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects. Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-a/interferon-g-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation. Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-a and interleukin-1b. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling.

Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalJournal of Ginseng Research
Volume41
Issue number2
DOIs
Publication statusPublished - 2017 Apr 1

Keywords

  • Anti-inflammatory activity
  • Ginsenoside Rc
  • P38
  • Panax ginseng
  • TANK-binding kinase 1

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Complementary and alternative medicine

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