Abstract
Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, antiinflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects. Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-a/interferon-g-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation. Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-a and interleukin-1b. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling.
| Original language | English |
|---|---|
| Pages (from-to) | 127-133 |
| Number of pages | 7 |
| Journal | Journal of Ginseng Research |
| Volume | 41 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2017 Apr 1 |
Fingerprint
Keywords
- Anti-inflammatory activity
- Ginsenoside Rc
- P38
- Panax ginseng
- TANK-binding kinase 1
ASJC Scopus subject areas
- Biotechnology
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Complementary and alternative medicine
Cite this
Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2. / Yu, Tao; Yang, Yanyan; Kwak, Yi Seong; Song, Gwan Gyu; Kim, Mi Yeon; Rhee, Man Hee; Cho, Jae Youl.
In: Journal of Ginseng Research, Vol. 41, No. 2, 01.04.2017, p. 127-133.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2
AU - Yu, Tao
AU - Yang, Yanyan
AU - Kwak, Yi Seong
AU - Song, Gwan Gyu
AU - Kim, Mi Yeon
AU - Rhee, Man Hee
AU - Cho, Jae Youl
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, antiinflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects. Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-a/interferon-g-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation. Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-a and interleukin-1b. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling.
AB - Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, antiinflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects. Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-a/interferon-g-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation. Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-a and interleukin-1b. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IkB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling.
KW - Anti-inflammatory activity
KW - Ginsenoside Rc
KW - P38
KW - Panax ginseng
KW - TANK-binding kinase 1
UR - http://www.scopus.com/inward/record.url?scp=85015574339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85015574339&partnerID=8YFLogxK
U2 - 10.1016/j.jgr.2016.02.001
DO - 10.1016/j.jgr.2016.02.001
M3 - Article
AN - SCOPUS:85015574339
VL - 41
SP - 127
EP - 133
JO - Journal of Ginseng Research
JF - Journal of Ginseng Research
SN - 1226-8453
IS - 2
ER -