Gliosarcoma is a distinct disease entity that is characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation. The tumor in our case was a rare morphologic variant of gliosarcoma with components of anaplastic oligodendrogliomia and unclassifiable spindle cells. Spindle cells showed CD34 and S-100 protein immunoreactivity which was possibly related to peripheral nerve sheath differentiation. This unique feature has not been described previously and so this case expands the spectrum of possible divergent mesenchymal differentiation, and it lends support to pluripotential stem cells being the origin of this tumor.
|Number of pages||5|
|Journal||Korean Journal of Pathology|
|Publication status||Published - 2008|
- Anaplastic oligodendroglioma
- S-100 protein
ASJC Scopus subject areas
- Pathology and Forensic Medicine