Abstract
Phylogenetic analysis of a collection of 103 E1 gene sequences from rubella viruses isolated from 17 countries from 1961 to 2000 confirmed the existence of at least two genotypes. Rubella genotype I (RGI) isolates, predominant in Europe, Japan, and the Western Hemisphere, segregated into discrete subgenotypes; international subgenotypes present in the 1960s and 1970s were replaced by geographically restricted subgenotypes after ∼1980. Recently, active subgenotypes include one in the United States and Latin America, one in China, and a third that apparently originated in Asia and spread to Europe and North America, starting in 1997, indicating the recent emergence of an international subgenotype. A virus that potentially arose as a recombinant between two RGI subgenotypes was discovered. Rubella genotype II (RGII) showed greater genetic diversity than did RGI and may actually consist of multiple genotypes. RGII viruses were limited to Asia and Europe; RGI viruses were also present in most of the countries where RGII viruses were isolated.
| Original language | English |
|---|---|
| Pages (from-to) | 1523-1530 |
| Number of pages | 8 |
| Journal | Emerging Infectious Diseases |
| Volume | 9 |
| Issue number | 12 |
| Publication status | Published - 2003 Dec 1 |
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ASJC Scopus subject areas
- Microbiology (medical)
Cite this
Global Distribution of Rubella Virus Genotypes. / Zheng, Du Ping; Frey, Teryl K.; Icenogle, Joseph; Katow, Shigetaka; Abernathy, Emily S.; Song, Ki-Joon; Xu, Wen Bo; Yarulin, Vitaly; Desjatskova, R. G.; Aboudy, Yair; Enders, Gisela; Croxson, Margaret.
In: Emerging Infectious Diseases, Vol. 9, No. 12, 01.12.2003, p. 1523-1530.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Global Distribution of Rubella Virus Genotypes
AU - Zheng, Du Ping
AU - Frey, Teryl K.
AU - Icenogle, Joseph
AU - Katow, Shigetaka
AU - Abernathy, Emily S.
AU - Song, Ki-Joon
AU - Xu, Wen Bo
AU - Yarulin, Vitaly
AU - Desjatskova, R. G.
AU - Aboudy, Yair
AU - Enders, Gisela
AU - Croxson, Margaret
PY - 2003/12/1
Y1 - 2003/12/1
N2 - Phylogenetic analysis of a collection of 103 E1 gene sequences from rubella viruses isolated from 17 countries from 1961 to 2000 confirmed the existence of at least two genotypes. Rubella genotype I (RGI) isolates, predominant in Europe, Japan, and the Western Hemisphere, segregated into discrete subgenotypes; international subgenotypes present in the 1960s and 1970s were replaced by geographically restricted subgenotypes after ∼1980. Recently, active subgenotypes include one in the United States and Latin America, one in China, and a third that apparently originated in Asia and spread to Europe and North America, starting in 1997, indicating the recent emergence of an international subgenotype. A virus that potentially arose as a recombinant between two RGI subgenotypes was discovered. Rubella genotype II (RGII) showed greater genetic diversity than did RGI and may actually consist of multiple genotypes. RGII viruses were limited to Asia and Europe; RGI viruses were also present in most of the countries where RGII viruses were isolated.
AB - Phylogenetic analysis of a collection of 103 E1 gene sequences from rubella viruses isolated from 17 countries from 1961 to 2000 confirmed the existence of at least two genotypes. Rubella genotype I (RGI) isolates, predominant in Europe, Japan, and the Western Hemisphere, segregated into discrete subgenotypes; international subgenotypes present in the 1960s and 1970s were replaced by geographically restricted subgenotypes after ∼1980. Recently, active subgenotypes include one in the United States and Latin America, one in China, and a third that apparently originated in Asia and spread to Europe and North America, starting in 1997, indicating the recent emergence of an international subgenotype. A virus that potentially arose as a recombinant between two RGI subgenotypes was discovered. Rubella genotype II (RGII) showed greater genetic diversity than did RGI and may actually consist of multiple genotypes. RGII viruses were limited to Asia and Europe; RGI viruses were also present in most of the countries where RGII viruses were isolated.
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UR - http://www.scopus.com/inward/citedby.url?scp=10744225896&partnerID=8YFLogxK
M3 - Article
C2 - 14720390
AN - SCOPUS:10744225896
VL - 9
SP - 1523
EP - 1530
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
SN - 1080-6040
IS - 12
ER -