Global Distribution of Rubella Virus Genotypes

Du Ping Zheng; Teryl K. Frey; Joseph Icenogle; Shigetaka Katow; Emily S. Abernathy; Ki Joon Song; Wen Bo Xu; Vitaly Yarulin; R. G. Desjatskova; Yair Aboudy; Gisela Enders; Margaret Croxson

doi:10.3201/eid0912.030242

Global Distribution of Rubella Virus Genotypes

Du Ping Zheng, Teryl K. Frey, Joseph Icenogle, Shigetaka Katow, Emily S. Abernathy, Ki Joon Song, Wen Bo Xu, Vitaly Yarulin, R. G. Desjatskova, Yair Aboudy, Gisela Enders, Margaret Croxson

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Phylogenetic analysis of a collection of 103 E1 gene sequences from rubella viruses isolated from 17 countries from 1961 to 2000 confirmed the existence of at least two genotypes. Rubella genotype I (RGI) isolates, predominant in Europe, Japan, and the Western Hemisphere, segregated into discrete subgenotypes; international subgenotypes present in the 1960s and 1970s were replaced by geographically restricted subgenotypes after ∼1980. Recently, active subgenotypes include one in the United States and Latin America, one in China, and a third that apparently originated in Asia and spread to Europe and North America, starting in 1997, indicating the recent emergence of an international subgenotype. A virus that potentially arose as a recombinant between two RGI subgenotypes was discovered. Rubella genotype II (RGII) showed greater genetic diversity than did RGI and may actually consist of multiple genotypes. RGII viruses were limited to Asia and Europe; RGI viruses were also present in most of the countries where RGII viruses were isolated.

Original language	English
Pages (from-to)	1523-1530
Number of pages	8
Journal	Emerging Infectious Diseases
Volume	9
Issue number	12
DOIs	https://doi.org/10.3201/eid0912.030242
Publication status	Published - 2003 Dec

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

UN SDGs

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10.3201/eid0912.030242

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Global Distribution of Rubella Virus Genotypes. / Zheng, Du Ping; Frey, Teryl K.; Icenogle, Joseph; Katow, Shigetaka; Abernathy, Emily S.; Song, Ki Joon; Xu, Wen Bo; Yarulin, Vitaly; Desjatskova, R. G.; Aboudy, Yair; Enders, Gisela; Croxson, Margaret.

In: Emerging Infectious Diseases, Vol. 9, No. 12, 12.2003, p. 1523-1530.

Research output: Contribution to journal › Article › peer-review

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abstract = "Phylogenetic analysis of a collection of 103 E1 gene sequences from rubella viruses isolated from 17 countries from 1961 to 2000 confirmed the existence of at least two genotypes. Rubella genotype I (RGI) isolates, predominant in Europe, Japan, and the Western Hemisphere, segregated into discrete subgenotypes; international subgenotypes present in the 1960s and 1970s were replaced by geographically restricted subgenotypes after ∼1980. Recently, active subgenotypes include one in the United States and Latin America, one in China, and a third that apparently originated in Asia and spread to Europe and North America, starting in 1997, indicating the recent emergence of an international subgenotype. A virus that potentially arose as a recombinant between two RGI subgenotypes was discovered. Rubella genotype II (RGII) showed greater genetic diversity than did RGI and may actually consist of multiple genotypes. RGII viruses were limited to Asia and Europe; RGI viruses were also present in most of the countries where RGII viruses were isolated.",

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AU - Xu, Wen Bo

AU - Yarulin, Vitaly

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AU - Aboudy, Yair

AU - Enders, Gisela

AU - Croxson, Margaret

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AB - Phylogenetic analysis of a collection of 103 E1 gene sequences from rubella viruses isolated from 17 countries from 1961 to 2000 confirmed the existence of at least two genotypes. Rubella genotype I (RGI) isolates, predominant in Europe, Japan, and the Western Hemisphere, segregated into discrete subgenotypes; international subgenotypes present in the 1960s and 1970s were replaced by geographically restricted subgenotypes after ∼1980. Recently, active subgenotypes include one in the United States and Latin America, one in China, and a third that apparently originated in Asia and spread to Europe and North America, starting in 1997, indicating the recent emergence of an international subgenotype. A virus that potentially arose as a recombinant between two RGI subgenotypes was discovered. Rubella genotype II (RGII) showed greater genetic diversity than did RGI and may actually consist of multiple genotypes. RGII viruses were limited to Asia and Europe; RGI viruses were also present in most of the countries where RGII viruses were isolated.

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Global Distribution of Rubella Virus Genotypes

Abstract

ASJC Scopus subject areas

UN SDGs

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