Global extent of horizontal gene transfer

In-Geol Choi, Sung Hou Kim

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Horizontal gene transfer (HGT) is thought to play an important role in the evolution of species and innovation of genomes. There have been many convincing evidences for HGT for specific genes or gene families, but there has been no estimate of the global extent of HGT. Here, we present a method of identifying HGT events within a given protein family and estimate the global extent of HGT in all curated protein domain families (≈8,000) listed in the Pfam database. The results suggest four conclusions: (i) for all protein domain families in Pfam, the fixation of genes horizontally transferred is not a rampant phenomenon between organisms with substantial phylogenetic separations (1.1-9.7% of Pfam families surveyed at three taxonomic ranges studied show indication of HGT); (ii) however, at the level of domains, >50% of Archaea have one or more protein domains acquired by HGT, and nearly 30-50% of Bacteria did the same when examined at three taxonomic ranges. But, the equivalent value for Eukarya is <10%; (iii) HGT will have very little impact in the construction of organism phylogeny, when the construction methods use whole genomes, large numbers of common genes, or SSU rRNAs; and (iv) there appears to be no strong preference of HGT for protein families of particular cellular or molecular functions.

Original languageEnglish
Pages (from-to)4489-4494
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number11
DOIs
Publication statusPublished - 2007 Mar 13

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Horizontal Gene Transfer
Genes
Genome
Archaea
Phylogeny
Eukaryota
Proteins
Databases
Bacteria

Keywords

  • Lateral gene transfer
  • Protein domain family
  • Protein sequence family

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Global extent of horizontal gene transfer. / Choi, In-Geol; Kim, Sung Hou.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 11, 13.03.2007, p. 4489-4494.

Research output: Contribution to journalArticle

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