GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal

Sukwon Lee, Beomjong Song, Jeongyeon Kim, Kyungjoon Park, Ingie Hong, Bobae An, Sangho Song, Jiwon Lee, Sungmo Park, Jihye Kim, Dongeun Park, Changjoon Lee, Kyungjin Kim, Ki Soon Shin, Richard W. Tsien, Sukwoo Choi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasticity, enhanced excitatory synaptic strength, activity of synaptic GluA2-lacking AMPA receptors and Ser831 phosphorylation of synaptic surface GluA1 in the lateral nucleus of the amygdala (LAn) of fear-extinguished rats. Consistently, the induction threshold for LAn synaptic potentiation was considerably lowered after extinction, and renewal occluded this low-threshold potentiation. The low-threshold potentiation (a potential cellular substrate for renewal), but not long-term potentiation, was attenuated by dialysis into LAn neurons of a GluA1-derived peptide that competes with Ser831-phosphorylated GluA1. Microinjections of the same peptide into the LAn attenuated fear renewal, but not fear learning. Our findings suggest that GluA1 phosphorylation constitutes a promising target for clinical treatment of aberrant fear-relateddisorders.

Original languageEnglish
Pages (from-to)1436-1444
Number of pages9
JournalNature Neuroscience
Volume16
Issue number10
DOIs
Publication statusPublished - 2013 Oct 1
Externally publishedYes

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Amygdala
Serine
Fear
Phosphorylation
Peptides
Neuronal Plasticity
AMPA Receptors
Phobic Disorders
Long-Term Potentiation
Microinjections
Post-Traumatic Stress Disorders
Dialysis
Learning
Neurons
Recurrence
Basolateral Nuclear Complex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lee, S., Song, B., Kim, J., Park, K., Hong, I., An, B., ... Choi, S. (2013). GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal. Nature Neuroscience, 16(10), 1436-1444. https://doi.org/10.1038/nn.3491

GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal. / Lee, Sukwon; Song, Beomjong; Kim, Jeongyeon; Park, Kyungjoon; Hong, Ingie; An, Bobae; Song, Sangho; Lee, Jiwon; Park, Sungmo; Kim, Jihye; Park, Dongeun; Lee, Changjoon; Kim, Kyungjin; Shin, Ki Soon; Tsien, Richard W.; Choi, Sukwoo.

In: Nature Neuroscience, Vol. 16, No. 10, 01.10.2013, p. 1436-1444.

Research output: Contribution to journalArticle

Lee, S, Song, B, Kim, J, Park, K, Hong, I, An, B, Song, S, Lee, J, Park, S, Kim, J, Park, D, Lee, C, Kim, K, Shin, KS, Tsien, RW & Choi, S 2013, 'GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal', Nature Neuroscience, vol. 16, no. 10, pp. 1436-1444. https://doi.org/10.1038/nn.3491
Lee, Sukwon ; Song, Beomjong ; Kim, Jeongyeon ; Park, Kyungjoon ; Hong, Ingie ; An, Bobae ; Song, Sangho ; Lee, Jiwon ; Park, Sungmo ; Kim, Jihye ; Park, Dongeun ; Lee, Changjoon ; Kim, Kyungjin ; Shin, Ki Soon ; Tsien, Richard W. ; Choi, Sukwoo. / GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal. In: Nature Neuroscience. 2013 ; Vol. 16, No. 10. pp. 1436-1444.
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