Glycation inhibitory activity and the identification of an active compound in Plantago asiatica extract

Soo Youn Choi, Sung Hoon Jung, Hyun Sun Lee, Kwen Woo Park, Bong Sik Yun, Kwang Won Lee

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

The glycation reaction involves a series of non-enzymatic reactions between the carbonyl group on reducing sugars and the amino group on proteins leading to the formation of advanced glycation end-products (AGEs), which are acknowledged to be involved in the pathogenesis of diabetic and aging-related complications. Consequently, the development of AGE inhibitors is considered to have therapeutic potential in patients with diabetes or age-related diseases. The preliminary results showed that a methanol extract (PAE) of Plantago asiatica, which is traditionally used as a folk medicine in Asian countries to treat fever, cough, wound etc., had strong glycation inhibitory activity. The effects of the extract on AGE fluorescence were dose-dependent, reaching 41% inhibition at 0.1 μg/mL of extract. The purified principle from PAE was identified as plantamajoside. As well as antioxidant activities, in vitro glycation inhibitory activities with 10 and 25 mM plantamajoside were higher than those with 10 and 25 mM aminoguanidine. The results demonstrate that PAE and plantamajoside had significant effects on in vitro AGE formation, and the glycation inhibitory activity and antioxidant activity of plantamajoside were comparable to those obtained using millimolar concentrations of the standard antiglycation agent aminoguanidine, and the antioxidant ascorbate, respectively.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalPhytotherapy Research
Volume22
Issue number3
DOIs
Publication statusPublished - 2008 Mar

Keywords

  • Advanded glycation end-products
  • Antioxidant
  • Maillard reaction
  • Plantago asiatica
  • Plantamajoside

ASJC Scopus subject areas

  • Pharmacology

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