Glycation inhibitory activity and the identification of an active compound in Plantago asiatica extract

Soo Youn Choi, Sung Hoon Jung, Hyun Sun Lee, Kwen Woo Park, Bong Sik Yun, Kwang Won Lee

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The glycation reaction involves a series of non-enzymatic reactions between the carbonyl group on reducing sugars and the amino group on proteins leading to the formation of advanced glycation end-products (AGEs), which are acknowledged to be involved in the pathogenesis of diabetic and aging-related complications. Consequently, the development of AGE inhibitors is considered to have therapeutic potential in patients with diabetes or age-related diseases. The preliminary results showed that a methanol extract (PAE) of Plantago asiatica, which is traditionally used as a folk medicine in Asian countries to treat fever, cough, wound etc., had strong glycation inhibitory activity. The effects of the extract on AGE fluorescence were dose-dependent, reaching 41% inhibition at 0.1 μg/mL of extract. The purified principle from PAE was identified as plantamajoside. As well as antioxidant activities, in vitro glycation inhibitory activities with 10 and 25 mM plantamajoside were higher than those with 10 and 25 mM aminoguanidine. The results demonstrate that PAE and plantamajoside had significant effects on in vitro AGE formation, and the glycation inhibitory activity and antioxidant activity of plantamajoside were comparable to those obtained using millimolar concentrations of the standard antiglycation agent aminoguanidine, and the antioxidant ascorbate, respectively.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalPhytotherapy Research
Volume22
Issue number3
DOIs
Publication statusPublished - 2008 Mar 1

Fingerprint

Plantago
Advanced Glycosylation End Products
Antioxidants
Amino Sugars
Traditional Medicine
Medical problems
Cough
Medicine
Methanol
Fever
Aging of materials
Fluorescence
plantamajoside
Wounds and Injuries
Proteins
In Vitro Techniques
pimagedine

Keywords

  • Advanded glycation end-products
  • Antioxidant
  • Maillard reaction
  • Plantago asiatica
  • Plantamajoside

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Glycation inhibitory activity and the identification of an active compound in Plantago asiatica extract. / Choi, Soo Youn; Jung, Sung Hoon; Lee, Hyun Sun; Park, Kwen Woo; Yun, Bong Sik; Lee, Kwang Won.

In: Phytotherapy Research, Vol. 22, No. 3, 01.03.2008, p. 323-329.

Research output: Contribution to journalArticle

Choi, Soo Youn ; Jung, Sung Hoon ; Lee, Hyun Sun ; Park, Kwen Woo ; Yun, Bong Sik ; Lee, Kwang Won. / Glycation inhibitory activity and the identification of an active compound in Plantago asiatica extract. In: Phytotherapy Research. 2008 ; Vol. 22, No. 3. pp. 323-329.
@article{9ca1293353f6404db6bbcd38fbb0796c,
title = "Glycation inhibitory activity and the identification of an active compound in Plantago asiatica extract",
abstract = "The glycation reaction involves a series of non-enzymatic reactions between the carbonyl group on reducing sugars and the amino group on proteins leading to the formation of advanced glycation end-products (AGEs), which are acknowledged to be involved in the pathogenesis of diabetic and aging-related complications. Consequently, the development of AGE inhibitors is considered to have therapeutic potential in patients with diabetes or age-related diseases. The preliminary results showed that a methanol extract (PAE) of Plantago asiatica, which is traditionally used as a folk medicine in Asian countries to treat fever, cough, wound etc., had strong glycation inhibitory activity. The effects of the extract on AGE fluorescence were dose-dependent, reaching 41{\%} inhibition at 0.1 μg/mL of extract. The purified principle from PAE was identified as plantamajoside. As well as antioxidant activities, in vitro glycation inhibitory activities with 10 and 25 mM plantamajoside were higher than those with 10 and 25 mM aminoguanidine. The results demonstrate that PAE and plantamajoside had significant effects on in vitro AGE formation, and the glycation inhibitory activity and antioxidant activity of plantamajoside were comparable to those obtained using millimolar concentrations of the standard antiglycation agent aminoguanidine, and the antioxidant ascorbate, respectively.",
keywords = "Advanded glycation end-products, Antioxidant, Maillard reaction, Plantago asiatica, Plantamajoside",
author = "Choi, {Soo Youn} and Jung, {Sung Hoon} and Lee, {Hyun Sun} and Park, {Kwen Woo} and Yun, {Bong Sik} and Lee, {Kwang Won}",
year = "2008",
month = "3",
day = "1",
doi = "10.1002/ptr.2316",
language = "English",
volume = "22",
pages = "323--329",
journal = "Phytotherapy Research",
issn = "0951-418X",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

TY - JOUR

T1 - Glycation inhibitory activity and the identification of an active compound in Plantago asiatica extract

AU - Choi, Soo Youn

AU - Jung, Sung Hoon

AU - Lee, Hyun Sun

AU - Park, Kwen Woo

AU - Yun, Bong Sik

AU - Lee, Kwang Won

PY - 2008/3/1

Y1 - 2008/3/1

N2 - The glycation reaction involves a series of non-enzymatic reactions between the carbonyl group on reducing sugars and the amino group on proteins leading to the formation of advanced glycation end-products (AGEs), which are acknowledged to be involved in the pathogenesis of diabetic and aging-related complications. Consequently, the development of AGE inhibitors is considered to have therapeutic potential in patients with diabetes or age-related diseases. The preliminary results showed that a methanol extract (PAE) of Plantago asiatica, which is traditionally used as a folk medicine in Asian countries to treat fever, cough, wound etc., had strong glycation inhibitory activity. The effects of the extract on AGE fluorescence were dose-dependent, reaching 41% inhibition at 0.1 μg/mL of extract. The purified principle from PAE was identified as plantamajoside. As well as antioxidant activities, in vitro glycation inhibitory activities with 10 and 25 mM plantamajoside were higher than those with 10 and 25 mM aminoguanidine. The results demonstrate that PAE and plantamajoside had significant effects on in vitro AGE formation, and the glycation inhibitory activity and antioxidant activity of plantamajoside were comparable to those obtained using millimolar concentrations of the standard antiglycation agent aminoguanidine, and the antioxidant ascorbate, respectively.

AB - The glycation reaction involves a series of non-enzymatic reactions between the carbonyl group on reducing sugars and the amino group on proteins leading to the formation of advanced glycation end-products (AGEs), which are acknowledged to be involved in the pathogenesis of diabetic and aging-related complications. Consequently, the development of AGE inhibitors is considered to have therapeutic potential in patients with diabetes or age-related diseases. The preliminary results showed that a methanol extract (PAE) of Plantago asiatica, which is traditionally used as a folk medicine in Asian countries to treat fever, cough, wound etc., had strong glycation inhibitory activity. The effects of the extract on AGE fluorescence were dose-dependent, reaching 41% inhibition at 0.1 μg/mL of extract. The purified principle from PAE was identified as plantamajoside. As well as antioxidant activities, in vitro glycation inhibitory activities with 10 and 25 mM plantamajoside were higher than those with 10 and 25 mM aminoguanidine. The results demonstrate that PAE and plantamajoside had significant effects on in vitro AGE formation, and the glycation inhibitory activity and antioxidant activity of plantamajoside were comparable to those obtained using millimolar concentrations of the standard antiglycation agent aminoguanidine, and the antioxidant ascorbate, respectively.

KW - Advanded glycation end-products

KW - Antioxidant

KW - Maillard reaction

KW - Plantago asiatica

KW - Plantamajoside

UR - http://www.scopus.com/inward/record.url?scp=40849085255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40849085255&partnerID=8YFLogxK

U2 - 10.1002/ptr.2316

DO - 10.1002/ptr.2316

M3 - Article

C2 - 18167045

AN - SCOPUS:40849085255

VL - 22

SP - 323

EP - 329

JO - Phytotherapy Research

JF - Phytotherapy Research

SN - 0951-418X

IS - 3

ER -