Glycol chitosan/heparin immobilized iron oxide nanoparticles with a tumor-targeting characteristic for magnetic resonance imaging

Soon Hong Yuk, Keun Sang Oh, Sun Hang Cho, Beom Suk Lee, Sang Yoon Kim, Byung Kook Kwak, Kwang Meyung Kim, Ick Chan Kwon

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

We described the preparation of the glycol chitosan/heparin immobilized iron oxide nanoparticles (composite NPs) as a magnetic resonance imaging agent with a tumor-targeting characteristic. The iron oxide nanoseeds used clinically as a magnetic resonance imaging agent were immobilized into the glycol chitosan/heparin network to form the composite NPs. To induce the ionic interaction between the iron oxide nanoseeds and glycol chitosan, gold was deposited on the surface of iron oxide nanoseeds. After the immobilization of gold-deposited iron oxide NPs into the glycol chitosan network, the NPs were stabilized with heparin based on the ionic interaction between cationic glycol chitosan and anionic heparin. FE-SEM (field emission-scanning electron microscopy) and a particle size analyzer were used to observe the formation of the stabilized composite NPs, and a Jobin-Yvon Ultima-C inductively coupled plasma-atomic emission spectrometer (ICP-AES) was used to measure the contents (%) of formed iron oxide nanoseeds as a function of reaction temperature and formed gold deposited on the iron oxide nanoparticles. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor-targeting ability of the composite NPs using a noninvasive NIR fluorescence imaging technology. To observe the MRI contrast characteristic, the composite NPs were injected into the tail veins of tumor-bearing mice to demonstrate their selective tumoral distribution. The MR images were collected with conventional T2-weighted spin echo acquisition parameters.

Original languageEnglish
Pages (from-to)2335-2343
Number of pages9
JournalBiomacromolecules
Volume12
Issue number6
DOIs
Publication statusPublished - 2011 Jun 13
Externally publishedYes

Fingerprint

Magnetic resonance
Glycols
Iron oxides
Chitosan
Heparin
Tumors
Nanoparticles
Imaging techniques
Gold
Composite materials
Bearings (structural)
Inductively coupled plasma
ferric oxide
glycol-chitosan
Field emission
Magnetic resonance imaging
Spectrometers
Fluorescence
Particle size
Scanning electron microscopy

ASJC Scopus subject areas

  • Bioengineering
  • Materials Chemistry
  • Polymers and Plastics
  • Biomaterials

Cite this

Glycol chitosan/heparin immobilized iron oxide nanoparticles with a tumor-targeting characteristic for magnetic resonance imaging. / Yuk, Soon Hong; Oh, Keun Sang; Cho, Sun Hang; Lee, Beom Suk; Kim, Sang Yoon; Kwak, Byung Kook; Kim, Kwang Meyung; Kwon, Ick Chan.

In: Biomacromolecules, Vol. 12, No. 6, 13.06.2011, p. 2335-2343.

Research output: Contribution to journalArticle

Yuk, Soon Hong ; Oh, Keun Sang ; Cho, Sun Hang ; Lee, Beom Suk ; Kim, Sang Yoon ; Kwak, Byung Kook ; Kim, Kwang Meyung ; Kwon, Ick Chan. / Glycol chitosan/heparin immobilized iron oxide nanoparticles with a tumor-targeting characteristic for magnetic resonance imaging. In: Biomacromolecules. 2011 ; Vol. 12, No. 6. pp. 2335-2343.
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