Glycolaldehyde-derived advanced glycation end products (glycol-AGEs)-induced vascular smooth muscle cell dysfunction is regulated by the AGES-receptor (RAGE) axis in endothelium

Mi Hyun Nam, Won Rak Son, Youngsik Lee, Kwang Won Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Advanced glycation end-products (AGEs) are involved in the development of vascular smooth muscle cell (VSMC) dysfunction and the progression of atherosclerosis. However, AGEs may indirectly affect VSMCs via AGEs-induced signal transduction between monocytes and human umbilical endothelial cells (HUVECs), rather than having a direct influence. This study was designed to elucidate the signaling pathway underlying AGEs-RAGE axis influence on VSMC dysfunction using a co-culture system with monocytes, HUVECs and VSMCs. AGEs stimulated production of reactive oxygen species and pro-inflammatory mediators such as tumor necrosis factor-α and interleukin-1β via extracellular-signal-regulated kinases phosphorylation and nuclear factor-κB activation in HUVECs. It was observed that AGEs-induced pro-inflammatory cytokines increase VSMC proliferation, inflammation and vascular remodeling in the co-culture system. This result implies that RAGE plays a role in AGEs-induced VSMC dysfunction. We suggest that the regulation of signal transduction via the AGEs-RAGE axis in the endothelium can be a therapeutic target for preventing atherosclerosis.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalCell Communication and Adhesion
DOIs
Publication statusAccepted/In press - 2016 Sep 7

Keywords

  • Advanced glycation end-products
  • inflammatory cytokines
  • reactive oxygen species
  • vascular dysfunction

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Biochemistry
  • Cell Biology

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