Abstract
Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.
| Original language | English |
|---|---|
| Pages (from-to) | 12353-12356 |
| Number of pages | 4 |
| Journal | Chemical communications (Cambridge, England) |
| Volume | 54 |
| Issue number | 87 |
| DOIs | |
| Publication status | Published - 2018 Oct 30 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
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Singh, H., Kim, S. J., Kang, D. H., Kim, H. R., Sharma, A., Kim, W. Y., Kang, C., & Kim, J. S. (2018). Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity. Chemical communications (Cambridge, England), 54(87), 12353-12356. https://doi.org/10.1039/c8cc05175e