Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

Hardev Singh; Seo Jin Kim; Dong Hoon Kang; Hye Ri Kim; Amit Sharma; Won Young Kim; Chulhun Kang; Jong Seung Kim

doi:10.1039/c8cc05175e

Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

Hardev Singh, Seo Jin Kim, Dong Hoon Kang, Hye Ri Kim, Amit Sharma, Won Young Kim, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.

Original language	English
Pages (from-to)	12353-12356
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	54
Issue number	87
DOIs	https://doi.org/10.1039/c8cc05175e
Publication status	Published - 2018 Oct 30

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity. / Singh, Hardev; Kim, Seo Jin; Kang, Dong Hoon; Kim, Hye Ri; Sharma, Amit; Kim, Won Young; Kang, Chulhun; Kim, Jong Seung.

In: Chemical communications (Cambridge, England), Vol. 54, No. 87, 30.10.2018, p. 12353-12356.

Research output: Contribution to journal › Article › peer-review

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abstract = "Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.",

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AU - Singh, Hardev

AU - Kim, Seo Jin

AU - Kang, Dong Hoon

AU - Kim, Hye Ri

AU - Sharma, Amit

AU - Kim, Won Young

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2018/10/30

Y1 - 2018/10/30

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AB - Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.

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ER -

Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

Abstract

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