Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

Hardev Singh; Seo Jin Kim; Dong Hoon Kang; Hye Ri Kim; Amit Sharma; Won Young Kim; Chulhun Kang; Jong Seung Kim

doi:10.1039/c8cc05175e

Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

Hardev Singh, Seo Jin Kim, Dong Hoon Kang, Hye Ri Kim, Amit Sharma, Won Young Kim, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.

Original language	English
Pages (from-to)	12353-12356
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	87
DOIs	https://doi.org/10.1039/c8cc05175e
Publication status	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c8cc05175e

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title = "Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity",

abstract = "Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.",

author = "Hardev Singh and Kim, {Seo Jin} and Kang, {Dong Hoon} and Kim, {Hye Ri} and Amit Sharma and Kim, {Won Young} and Chulhun Kang and Kim, {Jong Seung}",

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year = "2018",

doi = "10.1039/c8cc05175e",

language = "English",

volume = "54",

pages = "12353--12356",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

AU - Singh, Hardev

AU - Kim, Seo Jin

AU - Kang, Dong Hoon

AU - Kim, Hye Ri

AU - Sharma, Amit

AU - Kim, Won Young

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2018

Y1 - 2018

N2 - Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.

AB - Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.

UR - http://www.scopus.com/inward/record.url?scp=85055622506&partnerID=8YFLogxK

U2 - 10.1039/c8cc05175e

DO - 10.1039/c8cc05175e

M3 - Article

C2 - 30324188

AN - SCOPUS:85055622506

VL - 54

SP - 12353

EP - 12356

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 87

ER -

Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

Abstract

ASJC Scopus subject areas

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