Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

Hardev Singh, Seo Jin Kim, Dong Hoon Kang, Hye Ri Kim, Amit Sharma, Won Young Kim, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.

Original languageEnglish
Pages (from-to)12353-12356
Number of pages4
JournalChemical communications (Cambridge, England)
Volume54
Issue number87
DOIs
Publication statusPublished - 2018 Oct 30

Fingerprint

Glycyrrhetinic Acid
Drug Delivery Systems
Hepatocytes
Acids
Hepatocellular Carcinoma
Ligands
Molecules
Therapeutics

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity. / Singh, Hardev; Kim, Seo Jin; Kang, Dong Hoon; Kim, Hye Ri; Sharma, Amit; Kim, Won Young; Kang, Chulhun; Kim, Jong Seung.

In: Chemical communications (Cambridge, England), Vol. 54, No. 87, 30.10.2018, p. 12353-12356.

Research output: Contribution to journalArticle

Singh, Hardev ; Kim, Seo Jin ; Kang, Dong Hoon ; Kim, Hye Ri ; Sharma, Amit ; Kim, Won Young ; Kang, Chulhun ; Kim, Jong Seung. / Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity. In: Chemical communications (Cambridge, England). 2018 ; Vol. 54, No. 87. pp. 12353-12356.
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