Abstract
Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.
| Original language | English |
|---|---|
| Pages (from-to) | 12353-12356 |
| Number of pages | 4 |
| Journal | Chemical communications (Cambridge, England) |
| Volume | 54 |
| Issue number | 87 |
| DOIs | |
| Publication status | Published - 2018 Oct 30 |
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ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
Cite this
Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity. / Singh, Hardev; Kim, Seo Jin; Kang, Dong Hoon; Kim, Hye Ri; Sharma, Amit; Kim, Won Young; Kang, Chulhun; Kim, Jong Seung.
In: Chemical communications (Cambridge, England), Vol. 54, No. 87, 30.10.2018, p. 12353-12356.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity
AU - Singh, Hardev
AU - Kim, Seo Jin
AU - Kang, Dong Hoon
AU - Kim, Hye Ri
AU - Sharma, Amit
AU - Kim, Won Young
AU - Kang, Chulhun
AU - Kim, Jong Seung
PY - 2018/10/30
Y1 - 2018/10/30
N2 - Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.
AB - Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.
UR - http://www.scopus.com/inward/record.url?scp=85055622506&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055622506&partnerID=8YFLogxK
U2 - 10.1039/c8cc05175e
DO - 10.1039/c8cc05175e
M3 - Article
C2 - 30324188
AN - SCOPUS:85055622506
VL - 54
SP - 12353
EP - 12356
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 87
ER -