Gold nanoparticle embedded silicon nanowire biosensor for applications of label-free DNA detection

Seong Wan Ryu, Chang Hoon Kim, Jin Woo Han, Chung Jin Kim, Cheulhee Jung, Hyun Gyu Park, Yang Kyu Choi

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Gold nanoparticle (GN) embedded silicon nanowire (SiNW) configuration was proposed as a new biosensor for label-free DNA detection to enhance the sensitivity. The electric current flow between two terminals, a source and a drain electrode, were measured to sense the immobilization of probe oligonucleotides and their hybridization with target oligonucleotides. The complementary target oligonucleotide, breast cancer DNA with 1. pM, was sensed. In addition, its sensing mechanism and limit of detection (LOD) enhancement was investigated through simulation. The results support that the LOD can be improved by reducing the SiNW doping concentration. This emerging architecture combined nanostructure of spherical GN and SiNW has high potential as a label-free biosensor due to its facile fabrication process, high thermal stability, immobilization efficiency with a thiol-group in a self-assembled monolayer (SAM), and improved sensitivity.

Original languageEnglish
Pages (from-to)2182-2185
Number of pages4
JournalBiosensors and Bioelectronics
Volume25
Issue number9
DOIs
Publication statusPublished - 2010 May 1
Externally publishedYes

Fingerprint

Nanowires
Oligonucleotides
Biosensing Techniques
Silicon
Biosensors
Gold
Nanoparticles
Labels
DNA
Immobilization
Limit of Detection
Oligonucleotide Probes
Nanostructures
Self assembled monolayers
Electric currents
Sulfhydryl Compounds
Electrodes
Thermodynamic stability
Hot Temperature
Doping (additives)

Keywords

  • DNA
  • Gold nanoparticle
  • Hybridization
  • Oligonucleotide immobilization
  • Silicon nanowire

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

Cite this

Gold nanoparticle embedded silicon nanowire biosensor for applications of label-free DNA detection. / Ryu, Seong Wan; Kim, Chang Hoon; Han, Jin Woo; Kim, Chung Jin; Jung, Cheulhee; Park, Hyun Gyu; Choi, Yang Kyu.

In: Biosensors and Bioelectronics, Vol. 25, No. 9, 01.05.2010, p. 2182-2185.

Research output: Contribution to journalArticle

Ryu, Seong Wan ; Kim, Chang Hoon ; Han, Jin Woo ; Kim, Chung Jin ; Jung, Cheulhee ; Park, Hyun Gyu ; Choi, Yang Kyu. / Gold nanoparticle embedded silicon nanowire biosensor for applications of label-free DNA detection. In: Biosensors and Bioelectronics. 2010 ; Vol. 25, No. 9. pp. 2182-2185.
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