Gold nanoparticles as a potent radiosensitizer in neutron therapy

Eun Ho Kim, Mi Sook Kim, Hyo Sook Song, Seung Hoon Yoo, Sei Sai, Kwangzoo Chung, Jiwon Sung, Youn Kyoung Jeong, Yun Hui Jo, Myonggeun Yoon

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to investigate the potential of gold nanoparticles as radiosensitizer for use in neutron therapy against hepatocellular carcinoma. The hepatocellular carcinoma cells lines Huh7 and HepG2 were irradiated with γ and neutron radiation in the presence or absence of gold nanoparticles. Effects were evaluated by transmission electron microscopy, cell survival, cell cycle, DNA damage, migration, and invasiveness. Gold nanoparticles significantly enhanced the radiosensitivity of Huh7 and HepG2 cells to γ-rays by 1.41- and 1.16-fold, respectively, and by 1.80- and 1.35-fold to neutron radiation, which has high linear energy transfer. Accordingly, exposure to neutron radiation in the presence of gold nanoparticles induced cell cycle arrest, DNA damage, and cell death to a significantly higher extent, and suppressed cell migration and invasiveness more robustly. These effects are presumably due to the ability of gold nanoparticles to amplify the effective dose from neutron radiation more efficiently. The data suggest that gold nanoparticles may be clinically useful in combination therapy against hepatocellular carcinoma by enhancing the toxicity of radiation with high linear energy transfer.

Original languageEnglish
Pages (from-to)112390-112400
Number of pages11
JournalOncotarget
Volume8
Issue number68
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Neutrons
Gold
Nanoparticles
Radiation
Linear Energy Transfer
Hepatocellular Carcinoma
DNA Damage
Therapeutics
Radiation Tolerance
Hep G2 Cells
Cell Cycle Checkpoints
Transmission Electron Microscopy
Cell Movement
Cell Survival
Cell Cycle
Cell Death
Cell Line

Keywords

  • Cancer
  • Gold nanoparticles
  • Neutron therapy
  • Radiosensitizer
  • γ-ray

ASJC Scopus subject areas

  • Oncology

Cite this

Kim, E. H., Kim, M. S., Song, H. S., Yoo, S. H., Sai, S., Chung, K., ... Yoon, M. (2017). Gold nanoparticles as a potent radiosensitizer in neutron therapy. Oncotarget, 8(68), 112390-112400. https://doi.org/10.18632/oncotarget.19837

Gold nanoparticles as a potent radiosensitizer in neutron therapy. / Kim, Eun Ho; Kim, Mi Sook; Song, Hyo Sook; Yoo, Seung Hoon; Sai, Sei; Chung, Kwangzoo; Sung, Jiwon; Jeong, Youn Kyoung; Jo, Yun Hui; Yoon, Myonggeun.

In: Oncotarget, Vol. 8, No. 68, 01.01.2017, p. 112390-112400.

Research output: Contribution to journalArticle

Kim, EH, Kim, MS, Song, HS, Yoo, SH, Sai, S, Chung, K, Sung, J, Jeong, YK, Jo, YH & Yoon, M 2017, 'Gold nanoparticles as a potent radiosensitizer in neutron therapy', Oncotarget, vol. 8, no. 68, pp. 112390-112400. https://doi.org/10.18632/oncotarget.19837
Kim EH, Kim MS, Song HS, Yoo SH, Sai S, Chung K et al. Gold nanoparticles as a potent radiosensitizer in neutron therapy. Oncotarget. 2017 Jan 1;8(68):112390-112400. https://doi.org/10.18632/oncotarget.19837
Kim, Eun Ho ; Kim, Mi Sook ; Song, Hyo Sook ; Yoo, Seung Hoon ; Sai, Sei ; Chung, Kwangzoo ; Sung, Jiwon ; Jeong, Youn Kyoung ; Jo, Yun Hui ; Yoon, Myonggeun. / Gold nanoparticles as a potent radiosensitizer in neutron therapy. In: Oncotarget. 2017 ; Vol. 8, No. 68. pp. 112390-112400.
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