Gold nanorod-mediated photothermal modulation for localized ablation of cancer cells

Yoochan Hong, Eugene Lee, Jihye Choi, Seung Jae Oh, Seungjoo Haam, Yong Min Huh, Dae Sung Yoon, Jin Suck Suh, Jaemoon Yang

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Abstract

We estimated the photothermal transduction efficiency of gold nanorod (GNR) solutions for different GNR concentrations and irradiation laser power. In particular, we verified that the degree of cell death area could be modulated by GNR concentration and irradiation laser power. The efficacy of GNR-produced photothermal ablation of cancer cells was evaluated by irradiating GNRs in the presence of MDA-MB-231 breast cancer cells with a near-infrared (NIR) laser at different laser power densities and irradiation times. GNR-induced photothermal ablation was applied successfully to cancer cells at various NIR laser power densities and irradiation times and was characterized with live-dead cell staining. Through these techniques, we established the system for not only verification of induced photothermal effect using NIR laser and thermocouple, but also identification of uptake efficiency for GNRs and cell viability using dark field and fluorescence imaging, respectively.

Original languageEnglish
Article number825060
JournalJournal of Nanomaterials
Volume2012
DOIs
Publication statusPublished - 2012 Nov 16
Externally publishedYes

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ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Hong, Y., Lee, E., Choi, J., Oh, S. J., Haam, S., Huh, Y. M., ... Yang, J. (2012). Gold nanorod-mediated photothermal modulation for localized ablation of cancer cells. Journal of Nanomaterials, 2012, [825060]. https://doi.org/10.1155/2012/825060