Gold Nanotetrapods with Unique Topological Structure and Ultranarrow Plasmonic Band as Multifunctional Therapeutic Agents

Yi Xin Chang, Ning Ning Zhang, Yu Chen Xing, Qingfeng Zhang, Aram Oh, Hui Min Gao, Yun Zhu, Hionsuck Baik, Byeongyoon Kim, Yang Yang, Wei Shun Chang, Tianmeng Sun, Junhu Zhang, Zhong Yuan Lu, Kwangyeol Lee, Stephan Link, Kun Liu

Research output: Contribution to journalArticle

Abstract

Owing to their excellent surface plasmonic properties, Au nanobranches have drawn increasing attention in various bioapplications, such as contrast agents for photoacoustic imaging, nanomedicines for photothermal therapy, and carriers for drug delivery. The monodispersity and plasmonic bandwidth of Au nanobranches are of great importance for the efficacy of those bioapplications. However, it is still a challenge to accurately synthesize size- and shape-controlled Au nanobranches. Here we report a facile seed-mediated growth method to synthesize monodisperse Au nanotetrapods (NTPs) with tunable and ultranarrow plasmonic bands. The NTPs have a novel D2d symmetry with four arms elongated in four 110»directions. The growth mechanism of NTPs relies on the delicate kinetic control of deposition and diffusion rates of adatoms. Upon laser irradiation, the PEGylated NTPs possess remarkable photothermal conversion efficiencies and photoacoustic imaging properties. The NTPs can be applied as a multifunctional theranostic agent for both photoacoustic imaging and image-guided photothermal therapy.

Original languageEnglish
Pages (from-to)4505-4510
Number of pages6
JournalJournal of Physical Chemistry Letters
Volume10
Issue number16
DOIs
Publication statusPublished - 2019 Aug 15

ASJC Scopus subject areas

  • Materials Science(all)
  • Physical and Theoretical Chemistry

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    Chang, Y. X., Zhang, N. N., Xing, Y. C., Zhang, Q., Oh, A., Gao, H. M., Zhu, Y., Baik, H., Kim, B., Yang, Y., Chang, W. S., Sun, T., Zhang, J., Lu, Z. Y., Lee, K., Link, S., & Liu, K. (2019). Gold Nanotetrapods with Unique Topological Structure and Ultranarrow Plasmonic Band as Multifunctional Therapeutic Agents. Journal of Physical Chemistry Letters, 10(16), 4505-4510. https://doi.org/10.1021/acs.jpclett.9b01589