TY - JOUR
T1 - Gold-Polymer Nanocomposites for Future Therapeutic and Tissue Engineering Applications
AU - Kumar, Panangattukara Prabhakaran Praveen
AU - Lim, Dong Kwon
N1 - Funding Information:
Funding: This research was funded by National Research Foundation of Korea (2017M3D1A1039421).
Funding Information:
Acknowledgments: P.P.P.K. acknowledges the BK21 fellowship program. D.-K.L. acknowledges the support of National Research Foundation of Korea (2017M3D1A1039421), KU-KIST school program and Korea University.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/1
Y1 - 2022/1
N2 - Gold nanoparticles (AuNPs) have been extensively investigated for their use in various biomedical applications. Owing to their biocompatibility, simple surface modifications, and electrical and unique optical properties, AuNPs are considered promising nanomaterials for use in in vitro disease diagnosis, in vivo imaging, drug delivery, and tissue engineering applications. The functionality of AuNPs may be further expanded by producing hybrid nanocomposites with polymers that provide additional functions, responsiveness, and improved biocompatibility. Polymers may deliver large quantities of drugs or genes in therapeutic applications. A polymer alters the surface charges of AuNPs to improve or modulate cellular uptake efficiency and their biodistribution in the body. Furthermore, designing the functionality of nanocomposites to respond to an endo-or exogenous stimulus, such as pH, enzymes, or light, may facilitate the development of novel therapeutic applications. In this review, we focus on the recent progress in the use of AuNPs and Au-polymer nanocomposites in therapeutic applications such as drug or gene delivery, photothermal therapy, and tissue engineering.
AB - Gold nanoparticles (AuNPs) have been extensively investigated for their use in various biomedical applications. Owing to their biocompatibility, simple surface modifications, and electrical and unique optical properties, AuNPs are considered promising nanomaterials for use in in vitro disease diagnosis, in vivo imaging, drug delivery, and tissue engineering applications. The functionality of AuNPs may be further expanded by producing hybrid nanocomposites with polymers that provide additional functions, responsiveness, and improved biocompatibility. Polymers may deliver large quantities of drugs or genes in therapeutic applications. A polymer alters the surface charges of AuNPs to improve or modulate cellular uptake efficiency and their biodistribution in the body. Furthermore, designing the functionality of nanocomposites to respond to an endo-or exogenous stimulus, such as pH, enzymes, or light, may facilitate the development of novel therapeutic applications. In this review, we focus on the recent progress in the use of AuNPs and Au-polymer nanocomposites in therapeutic applications such as drug or gene delivery, photothermal therapy, and tissue engineering.
KW - Drug delivery
KW - Gold nanoparticles
KW - Photodynamic therapy
KW - Photothermal therapy
KW - Polymers
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85122137056&partnerID=8YFLogxK
U2 - 10.3390/pharmaceutics14010070
DO - 10.3390/pharmaceutics14010070
M3 - Review article
AN - SCOPUS:85122137056
SN - 1999-4923
VL - 14
JO - Pharmaceutics
JF - Pharmaceutics
IS - 1
M1 - 70
ER -