Green tea extract (Camellia sinensis) fermented by lactobacillus fermentum attenuates alcohol-induced liver damage

Jong Ho Park, Younghoon Kim, Sae Hun Kim

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Here, the impact of an extract derived from green tea (Camellia sinensis) and fermentation with Lactobacilli fermentum strain OCS19 was explored with acute alcohol-induced liver damage. The study employed the HepG2 hepatic cell line and an in vivo murine model of liver damage. L. fermentum-fermented green tea extract (FGTE) was found to possess pronounced alcohol metabolizing enzyme activity. It significantly enhanced the cell viability of HepG2 cells following of them exposure, to ethanol (p < 0:05) as compared with an extract derived from Hovenia dulcis, a positive control that is known for its action as an alcohol antagonist. Our in vivo studies indicated that prior administration of FGTE to alcohol-exposed mice significantly prevented subsequent increases in blood alcohol concentration (p < 0:05), in addition to the induction of serum alanine aminotransferase (ALT) and triglycerides (p < 0:05). Furthermore, the activity of hepatic alcohol dehydrogenase (ADH) and its mRNA expression level both increased in the livers of mice treated with FGTE, similarly to the H. dulcis-treated group. Taken together, these results may suggest that green tea extract coupled with L. fermentum fermentation attenuates the risk of ethanol-induced liver damage.

Original languageEnglish
Pages (from-to)2294-2300
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number12
DOIs
Publication statusPublished - 2012 Dec 1

Fingerprint

Lactobacillus fermentum
Camellia sinensis
Tea
Liver
Alcohols
Hep G2 Cells
Fermentation
Ethanol
Alcohol Dehydrogenase
Enzyme activity
Alanine Transaminase
Hepatocytes
Cell Survival
Triglycerides
Blood
Cells
Cell Line
Messenger RNA
Enzymes
Serum

Keywords

  • Alcohol-induced liver damage
  • Fermented green tea extract
  • Lactobacillus fermentum

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Green tea extract (Camellia sinensis) fermented by lactobacillus fermentum attenuates alcohol-induced liver damage. / Park, Jong Ho; Kim, Younghoon; Kim, Sae Hun.

In: Bioscience, Biotechnology and Biochemistry, Vol. 76, No. 12, 01.12.2012, p. 2294-2300.

Research output: Contribution to journalArticle

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