Group-and home-based cognitive intervention for patients with mild cognitive impairment: A randomized controlled trial

Jee Hyang Jeong, Hae Ri Na, Seong Hye Choi, Jungeun Kim, Duk L. Na, Sang Won Seo, Juhee Chin, Sun Ah Park, Eun Joo Kim, Hyun Jeong Han, Seol Heui Han, Soo Jin Yoon, Jae Hong Lee, Kyung Won Park, So Young Moon, Moon Ho Park, Mun Seong Choi, Il Woo Han, Jun Hong Lee, Jung Seok LeeYong S. Shim, Jeong Yeon Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: We examined the efficacy of group-based cognitive intervention (GCI) and home-based cognitive intervention (HCI) in amnestic mild cognitive impairment (aMCI) and intervention effects on serum brain-derived neuro- trophic factor (BDNF). Methods: In this randomized and rater- blinded trial, 293 patients with aMCI from 18 nationwide hospitals were randomized: 96 to the GCI group, 98 to the HCI group and 99 to the control group. For 12 weeks, subjects receiving GCI participated twice per week in group sessions led by trained instructors, and those receiving HCI completed homework materials 5 days per week. They were assessed at baseline, postintervention (PI) and at the 6-month follow-up after the intervention. The primary endpoint was the change from baseline to PI in the modified Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog). Results: In comparison to the controls (a 0.8-point decrease), the subjects receiving GCI (a 2.3-point decrease, p = 0.01) or HCI (a 2.5-point decrease, p = 0.02) showed significant improvements in the modified ADAS-Cog at PI, respectively. By the 6-month follow-up, those receiving GCI or HCI had better scores in the m odified ADAS-Cog than the controls. The changes in BDNF levels significantly correlated with the changes in the modified ADAS-Cog in the GCI (r = '0.29, p = 0.02 at PI) and HCI (r = '0.27, p = 0.03 at 6-month follow-up) groups, respectively. Conclusions: The GCI and HCI resulted in cognitive improvements in aMCI. An enhanced brain plasticity may be a component of the mechanism underpinning the cognitive improvements associated with the cognitive interventions.

Original languageEnglish
Pages (from-to)198-207
Number of pages10
JournalPsychotherapy and Psychosomatics
Volume85
Issue number4
DOIs
Publication statusPublished - 2016 Jun 14

Fingerprint

Group Homes
Alzheimer Disease
Randomized Controlled Trials
Brain
Control Groups
Cognitive Dysfunction
Serum

Keywords

  • Brain plasticity
  • Brain-derived neurotrophic factor
  • Cognition training
  • Conitive intervention
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Clinical Psychology
  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Group-and home-based cognitive intervention for patients with mild cognitive impairment : A randomized controlled trial. / Jeong, Jee Hyang; Na, Hae Ri; Choi, Seong Hye; Kim, Jungeun; Na, Duk L.; Seo, Sang Won; Chin, Juhee; Park, Sun Ah; Kim, Eun Joo; Han, Hyun Jeong; Han, Seol Heui; Yoon, Soo Jin; Lee, Jae Hong; Park, Kyung Won; Moon, So Young; Park, Moon Ho; Choi, Mun Seong; Han, Il Woo; Lee, Jun Hong; Lee, Jung Seok; Shim, Yong S.; Kim, Jeong Yeon.

In: Psychotherapy and Psychosomatics, Vol. 85, No. 4, 14.06.2016, p. 198-207.

Research output: Contribution to journalArticle

Jeong, JH, Na, HR, Choi, SH, Kim, J, Na, DL, Seo, SW, Chin, J, Park, SA, Kim, EJ, Han, HJ, Han, SH, Yoon, SJ, Lee, JH, Park, KW, Moon, SY, Park, MH, Choi, MS, Han, IW, Lee, JH, Lee, JS, Shim, YS & Kim, JY 2016, 'Group-and home-based cognitive intervention for patients with mild cognitive impairment: A randomized controlled trial', Psychotherapy and Psychosomatics, vol. 85, no. 4, pp. 198-207. https://doi.org/10.1159/000442261
Jeong, Jee Hyang ; Na, Hae Ri ; Choi, Seong Hye ; Kim, Jungeun ; Na, Duk L. ; Seo, Sang Won ; Chin, Juhee ; Park, Sun Ah ; Kim, Eun Joo ; Han, Hyun Jeong ; Han, Seol Heui ; Yoon, Soo Jin ; Lee, Jae Hong ; Park, Kyung Won ; Moon, So Young ; Park, Moon Ho ; Choi, Mun Seong ; Han, Il Woo ; Lee, Jun Hong ; Lee, Jung Seok ; Shim, Yong S. ; Kim, Jeong Yeon. / Group-and home-based cognitive intervention for patients with mild cognitive impairment : A randomized controlled trial. In: Psychotherapy and Psychosomatics. 2016 ; Vol. 85, No. 4. pp. 198-207.
@article{99fed76b99a84543ac537a6bab347cf9,
title = "Group-and home-based cognitive intervention for patients with mild cognitive impairment: A randomized controlled trial",
abstract = "Background: We examined the efficacy of group-based cognitive intervention (GCI) and home-based cognitive intervention (HCI) in amnestic mild cognitive impairment (aMCI) and intervention effects on serum brain-derived neuro- trophic factor (BDNF). Methods: In this randomized and rater- blinded trial, 293 patients with aMCI from 18 nationwide hospitals were randomized: 96 to the GCI group, 98 to the HCI group and 99 to the control group. For 12 weeks, subjects receiving GCI participated twice per week in group sessions led by trained instructors, and those receiving HCI completed homework materials 5 days per week. They were assessed at baseline, postintervention (PI) and at the 6-month follow-up after the intervention. The primary endpoint was the change from baseline to PI in the modified Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog). Results: In comparison to the controls (a 0.8-point decrease), the subjects receiving GCI (a 2.3-point decrease, p = 0.01) or HCI (a 2.5-point decrease, p = 0.02) showed significant improvements in the modified ADAS-Cog at PI, respectively. By the 6-month follow-up, those receiving GCI or HCI had better scores in the m odified ADAS-Cog than the controls. The changes in BDNF levels significantly correlated with the changes in the modified ADAS-Cog in the GCI (r = '0.29, p = 0.02 at PI) and HCI (r = '0.27, p = 0.03 at 6-month follow-up) groups, respectively. Conclusions: The GCI and HCI resulted in cognitive improvements in aMCI. An enhanced brain plasticity may be a component of the mechanism underpinning the cognitive improvements associated with the cognitive interventions.",
keywords = "Brain plasticity, Brain-derived neurotrophic factor, Cognition training, Conitive intervention, Mild cognitive impairment",
author = "Jeong, {Jee Hyang} and Na, {Hae Ri} and Choi, {Seong Hye} and Jungeun Kim and Na, {Duk L.} and Seo, {Sang Won} and Juhee Chin and Park, {Sun Ah} and Kim, {Eun Joo} and Han, {Hyun Jeong} and Han, {Seol Heui} and Yoon, {Soo Jin} and Lee, {Jae Hong} and Park, {Kyung Won} and Moon, {So Young} and Park, {Moon Ho} and Choi, {Mun Seong} and Han, {Il Woo} and Lee, {Jun Hong} and Lee, {Jung Seok} and Shim, {Yong S.} and Kim, {Jeong Yeon}",
year = "2016",
month = "6",
day = "14",
doi = "10.1159/000442261",
language = "English",
volume = "85",
pages = "198--207",
journal = "Psychotherapy and Psychosomatics",
issn = "0033-3190",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Group-and home-based cognitive intervention for patients with mild cognitive impairment

T2 - A randomized controlled trial

AU - Jeong, Jee Hyang

AU - Na, Hae Ri

AU - Choi, Seong Hye

AU - Kim, Jungeun

AU - Na, Duk L.

AU - Seo, Sang Won

AU - Chin, Juhee

AU - Park, Sun Ah

AU - Kim, Eun Joo

AU - Han, Hyun Jeong

AU - Han, Seol Heui

AU - Yoon, Soo Jin

AU - Lee, Jae Hong

AU - Park, Kyung Won

AU - Moon, So Young

AU - Park, Moon Ho

AU - Choi, Mun Seong

AU - Han, Il Woo

AU - Lee, Jun Hong

AU - Lee, Jung Seok

AU - Shim, Yong S.

AU - Kim, Jeong Yeon

PY - 2016/6/14

Y1 - 2016/6/14

N2 - Background: We examined the efficacy of group-based cognitive intervention (GCI) and home-based cognitive intervention (HCI) in amnestic mild cognitive impairment (aMCI) and intervention effects on serum brain-derived neuro- trophic factor (BDNF). Methods: In this randomized and rater- blinded trial, 293 patients with aMCI from 18 nationwide hospitals were randomized: 96 to the GCI group, 98 to the HCI group and 99 to the control group. For 12 weeks, subjects receiving GCI participated twice per week in group sessions led by trained instructors, and those receiving HCI completed homework materials 5 days per week. They were assessed at baseline, postintervention (PI) and at the 6-month follow-up after the intervention. The primary endpoint was the change from baseline to PI in the modified Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog). Results: In comparison to the controls (a 0.8-point decrease), the subjects receiving GCI (a 2.3-point decrease, p = 0.01) or HCI (a 2.5-point decrease, p = 0.02) showed significant improvements in the modified ADAS-Cog at PI, respectively. By the 6-month follow-up, those receiving GCI or HCI had better scores in the m odified ADAS-Cog than the controls. The changes in BDNF levels significantly correlated with the changes in the modified ADAS-Cog in the GCI (r = '0.29, p = 0.02 at PI) and HCI (r = '0.27, p = 0.03 at 6-month follow-up) groups, respectively. Conclusions: The GCI and HCI resulted in cognitive improvements in aMCI. An enhanced brain plasticity may be a component of the mechanism underpinning the cognitive improvements associated with the cognitive interventions.

AB - Background: We examined the efficacy of group-based cognitive intervention (GCI) and home-based cognitive intervention (HCI) in amnestic mild cognitive impairment (aMCI) and intervention effects on serum brain-derived neuro- trophic factor (BDNF). Methods: In this randomized and rater- blinded trial, 293 patients with aMCI from 18 nationwide hospitals were randomized: 96 to the GCI group, 98 to the HCI group and 99 to the control group. For 12 weeks, subjects receiving GCI participated twice per week in group sessions led by trained instructors, and those receiving HCI completed homework materials 5 days per week. They were assessed at baseline, postintervention (PI) and at the 6-month follow-up after the intervention. The primary endpoint was the change from baseline to PI in the modified Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog). Results: In comparison to the controls (a 0.8-point decrease), the subjects receiving GCI (a 2.3-point decrease, p = 0.01) or HCI (a 2.5-point decrease, p = 0.02) showed significant improvements in the modified ADAS-Cog at PI, respectively. By the 6-month follow-up, those receiving GCI or HCI had better scores in the m odified ADAS-Cog than the controls. The changes in BDNF levels significantly correlated with the changes in the modified ADAS-Cog in the GCI (r = '0.29, p = 0.02 at PI) and HCI (r = '0.27, p = 0.03 at 6-month follow-up) groups, respectively. Conclusions: The GCI and HCI resulted in cognitive improvements in aMCI. An enhanced brain plasticity may be a component of the mechanism underpinning the cognitive improvements associated with the cognitive interventions.

KW - Brain plasticity

KW - Brain-derived neurotrophic factor

KW - Cognition training

KW - Conitive intervention

KW - Mild cognitive impairment

UR - http://www.scopus.com/inward/record.url?scp=84975770253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975770253&partnerID=8YFLogxK

U2 - 10.1159/000442261

DO - 10.1159/000442261

M3 - Article

C2 - 27230861

AN - SCOPUS:84975770253

VL - 85

SP - 198

EP - 207

JO - Psychotherapy and Psychosomatics

JF - Psychotherapy and Psychosomatics

SN - 0033-3190

IS - 4

ER -