Groupwise registration from exemplar to group mean: Extending HAMMER to groupwise registration

Guorong Wu, Pew Thian Yap, Qian Wang, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)

Abstract

We extend the pairwise HAMMER registration algorithm to work in a groupwise manner for improving structural alignment of different individual brain images of a group. To achieve this, a tentative group mean is first generated from the previous aligned brain images (initially with affine registration), and all brain images are then registered onto the tentative group mean by HAMMER to obtain a refined group mean. Eventually, by repeating these two steps, a refined group mean image can be constructed. To obtain a better estimate of the group mean, we propose to average the aligned image according to anatomical shape, instead of intensity. Also, to alleviate possible large anatomical misalignment in the initial stages of the registration, a minimum risk estimator is employed for refining the correspondences before averaging, to prevent averaging across irrelevant anatomical structures, which, if not avoided, will render the group mean fuzzy. The performance of our groupwise registration method is evaluated by using real data (NIREP) in a ROI overlap analysis, and simulated data in an atrophy detection experiment. The results show that our groupwise registration algorithm yields better performance in both registration consistency and accuracy than the original pairwise HAMMER algorithm.

Original languageEnglish
Title of host publication2010 7th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2010 - Proceedings
Pages396-399
Number of pages4
DOIs
Publication statusPublished - 2010
Event7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Rotterdam, Netherlands
Duration: 2010 Apr 142010 Apr 17

Publication series

Name2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings

Other

Other7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010
CountryNetherlands
CityRotterdam
Period10/4/1410/4/17

Keywords

  • Exemplar image
  • Groupwise registration

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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    Wu, G., Yap, P. T., Wang, Q., & Shen, D. (2010). Groupwise registration from exemplar to group mean: Extending HAMMER to groupwise registration. In 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings (pp. 396-399). [5490327] (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings). https://doi.org/10.1109/ISBI.2010.5490327