Guidelines for the standardized collection of blood-based biomarkers in psychiatry: Steps for laboratory validity–a consensus of the Biomarkers Task Force from the WFSBP

Ana C. Andreazza, Isabelle Laksono, Brisa S. Fernandes, Catherine Toben, Piotr Lewczuk, Peter Riederer, Sidney H. Kennedy, Dimitrios Kapogiannis, Florence Thibaut, Manfred Gerlach, Carla Gallo, Yong Ku Kim, Edna Grünblatt, Lakshmi Yatham, Michael Berk, Bernhard T. Baune

    Research output: Contribution to journalReview articlepeer-review

    10 Citations (Scopus)

    Abstract

    Recently, there has been a major shift in the field of psychiatry towards the exploration of complex relationships between blood-based biomarkers and the pathophysiology of psychiatric and neuropsychiatric disorders. However, issues with study reproducibility, validity and reliability have hindered progress towards the identification of clinically relevant biomarkers for psychiatry. The achievement of laboratory validity is a crucial first step for the posterior development of clinical validity. There is evidence that the variability observed in blood-based research studies may be minimised with the implementation of standardised pre-analytical methods and uniform clinical protocols (i.e., pre-venipuncture). It has been documented that errors made in the pre-analytical phase account for 46–68.2% of laboratory testing errors. Thus, standardising clinical assessment, ethical procedures and pre-analytical phase of clinical research is essential for the reproducibility, validity and reliability of blood marker assessment, and reducing the risk of invalid test results. Various other areas of research have already moved towards guidelines for the standardised collection of blood-based biomarkers. Here we aim to provide a set of guidelines that we believe would improve biomarker research: (1) pre-venipuncture information and documentation, (2) ethics of participant consent and (3) pre-analytical methods. Ultimately, we hope this will assist study planning and will improve data comparison across studies allowing for the discovery of biomarkers in psychiatry with both laboratorial and clinical validity.

    Original languageEnglish
    Pages (from-to)340-351
    Number of pages12
    JournalWorld Journal of Biological Psychiatry
    Volume20
    Issue number5
    DOIs
    Publication statusPublished - 2019 May 28

    Keywords

    • Biomarkers
    • guidelines
    • reliability
    • standardisation
    • validity

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry

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