Gut microbiota in inflammatory bowel disease

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesis of inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along with a genetic predisposition. Recent views have suggested an excessive response to components of the gut microbiota in IBD. A condition of "dysbiosis", with alterations of the gut microbial composition, has been observed in patients with IBD. In this article, the author review recent studies of gut microbiota in IBD, particularly the importance of the gut microbiota in the pathogenesis of pediatric IBD.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalPediatric Gastroenterology, Hepatology and Nutrition
Volume16
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

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Inflammatory Bowel Diseases
Dysbiosis
Mucosal Immunity
Genetic Predisposition to Disease
Homeostasis
Gastrointestinal Microbiome
Pediatrics

Keywords

  • Child
  • Inflammatory bowel diseases
  • Microbiota

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology
  • Hepatology

Cite this

Gut microbiota in inflammatory bowel disease. / Shim, Jung Ok.

In: Pediatric Gastroenterology, Hepatology and Nutrition, Vol. 16, No. 1, 01.01.2013, p. 17-21.

Research output: Contribution to journalReview article

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