Gut microbiota in inflammatory bowel disease

Jung Ok Shim

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesis of inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along with a genetic predisposition. Recent views have suggested an excessive response to components of the gut microbiota in IBD. A condition of "dysbiosis", with alterations of the gut microbial composition, has been observed in patients with IBD. In this article, the author review recent studies of gut microbiota in IBD, particularly the importance of the gut microbiota in the pathogenesis of pediatric IBD.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalPediatric Gastroenterology, Hepatology and Nutrition
Volume16
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • Child
  • Inflammatory bowel diseases
  • Microbiota

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hepatology
  • Gastroenterology

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