Gut microbiota in inflammatory bowel disease

Jung Ok Shim

    Research output: Contribution to journalReview articlepeer-review

    38 Citations (Scopus)

    Abstract

    The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesis of inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along with a genetic predisposition. Recent views have suggested an excessive response to components of the gut microbiota in IBD. A condition of "dysbiosis", with alterations of the gut microbial composition, has been observed in patients with IBD. In this article, the author review recent studies of gut microbiota in IBD, particularly the importance of the gut microbiota in the pathogenesis of pediatric IBD.

    Original languageEnglish
    Pages (from-to)17-21
    Number of pages5
    JournalPediatric Gastroenterology, Hepatology and Nutrition
    Volume16
    Issue number1
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Child
    • Inflammatory bowel diseases
    • Microbiota

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Hepatology
    • Gastroenterology

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