GWA meta-analysis of personality in Korean cohorts

Bo Hye Kim, Han Na Kim, Seung Ju Roh, Mi Kyeong Lee, Sarah Yang, Seung Ku Lee, Yeon Ah Sung, Hye Won Chung, Nam H. Cho, Chol Shin, Joohon Sung, Hyung Lae Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Personality is a determinant of behavior and lifestyle that is associated with health and human diseases. Despite the heritability of personality traits is well established, the understanding of the genetic contribution to personality trait variation is extremely limited. To identify genetic variants associated with each of the five dimensions of personality, we performed a genome-wide association (GWA) meta-analysis of three cohorts, followed by comparison of a family cohort. Personality traits were measured with the Revised NEO Personality Inventory for the five-factor model (FFM) of personality. We investigated the top five single-nucleotide polymorphisms (SNPs) for each trait, and revealed the most highly association with neuroticism and TACC2 (rs1010657, P=8.79 10<sup>-7</sup>), extraversion and PTPN12 (rs12537271, P=1.47 10<sup>-7</sup>), openness and IMPAD1 (rs16921695, P=5 10<sup>-8</sup>), agreeableness and RPS29 (rs8015351, P=1.27 × 10<sup>-6</sup>) and conscientiousness and LMO4 (rs912765, P=2.91 10<sup>-6</sup>). It had no SNP reached the GWA study threshold (P<5 10<sup>-8</sup>). When expanded the SNPs up to top 100, the correlation of PTPRD (rs1029089) and agreeableness was confirmed in Healthy Twin cohort with other 13 SNPs. This GWA meta-analysis on FFM personality traits is meaningful as it was the first on a non-Caucasian population targeted to FFM of personality traits.

Original languageEnglish
Pages (from-to)455-460
Number of pages6
JournalJournal of Human Genetics
Volume60
Issue number8
DOIs
Publication statusPublished - 2015 Aug 26

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Fingerprint Dive into the research topics of 'GWA meta-analysis of personality in Korean cohorts'. Together they form a unique fingerprint.

  • Cite this

    Kim, B. H., Kim, H. N., Roh, S. J., Lee, M. K., Yang, S., Lee, S. K., Sung, Y. A., Chung, H. W., Cho, N. H., Shin, C., Sung, J., & Kim, H. L. (2015). GWA meta-analysis of personality in Korean cohorts. Journal of Human Genetics, 60(8), 455-460. https://doi.org/10.1038/jhg.2015.52