Abstract
Hemoglobin A1c (HbA1c) is an indicator of long-term glycemic control. The purpose of this study was to determine whether habitual snoring is associated with increased HbA1c levels in non-obese and normoglycemic middle-aged men and women. A total of 6981 subjects (3362 men and 3619 women) aged 40-69 years from the Korean Health and Genome Study were examined for the study. Each participant received a comprehensive physical examination as well as a set of questions pertaining to demographic characteristics and snoring frequency. Habitual snoring was defined as a snoring frequency of ≥4 days week-1. After adjusting for age, abdominal obesity, and other confounding covariates, male habitual snorers showed a 1.69-fold excess [95% confidence interval (CI) 1.30-2.19] odds of having a high HbA1c level. Similarly, premenopausal women with habitual snoring had a 2.31 times (95% CI 1.22-4.39) significantly higher odds of having elevated HbA1clevels compared with non-snorers. This association was not found in postmenopausal women. Multivariate analysis revealed that male habitual snorers aged 40-50 had a 2.08-fold excess (95% CI 1.40-3.09) risk of having an elevated HbA1c level. In male habitual snores over 50, the strength of association was attenuated. Our findings based on cross-sectional data support a hypothesis that habitual snoring is associated with impaired glucose tolerance even in non-obese and normoglycemic men and premenopausal women. However, as waist circumference as an index of abdominal obesity (visceral adiposity) in the present study may only partially represent the effect of visceral fat, there may be a residual confounding from visceral obesity in our result. Longitudinal follow-up studies are necessary to confirm the association between sleep-disordered breathing and impaired glucose tolerance and to examine the causal relationship in a healthy population without obesity and diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 437-444 |
| Number of pages | 8 |
| Journal | Journal of Sleep Research |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2006 Dec 1 |
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Keywords
- Hemoglobin a
- Impaired glucose tolerance
- Menopause
- Sleep disorders
ASJC Scopus subject areas
- Neuroscience(all)
- Physiology
Cite this
Habitual snoring is associated with elevated hemoglobin A1c levels in non-obese middle-aged adults. / Joo, Soonjae; Lee, Seungmin; Choi, Huimahn A.; Kim, Jinkwan; Kim, Eunhee; Kimm, Kuchan; Kim, Je Hyeong; Shin, Chol.
In: Journal of Sleep Research, Vol. 15, No. 4, 01.12.2006, p. 437-444.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Habitual snoring is associated with elevated hemoglobin A1c levels in non-obese middle-aged adults
AU - Joo, Soonjae
AU - Lee, Seungmin
AU - Choi, Huimahn A.
AU - Kim, Jinkwan
AU - Kim, Eunhee
AU - Kimm, Kuchan
AU - Kim, Je Hyeong
AU - Shin, Chol
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Hemoglobin A1c (HbA1c) is an indicator of long-term glycemic control. The purpose of this study was to determine whether habitual snoring is associated with increased HbA1c levels in non-obese and normoglycemic middle-aged men and women. A total of 6981 subjects (3362 men and 3619 women) aged 40-69 years from the Korean Health and Genome Study were examined for the study. Each participant received a comprehensive physical examination as well as a set of questions pertaining to demographic characteristics and snoring frequency. Habitual snoring was defined as a snoring frequency of ≥4 days week-1. After adjusting for age, abdominal obesity, and other confounding covariates, male habitual snorers showed a 1.69-fold excess [95% confidence interval (CI) 1.30-2.19] odds of having a high HbA1c level. Similarly, premenopausal women with habitual snoring had a 2.31 times (95% CI 1.22-4.39) significantly higher odds of having elevated HbA1clevels compared with non-snorers. This association was not found in postmenopausal women. Multivariate analysis revealed that male habitual snorers aged 40-50 had a 2.08-fold excess (95% CI 1.40-3.09) risk of having an elevated HbA1c level. In male habitual snores over 50, the strength of association was attenuated. Our findings based on cross-sectional data support a hypothesis that habitual snoring is associated with impaired glucose tolerance even in non-obese and normoglycemic men and premenopausal women. However, as waist circumference as an index of abdominal obesity (visceral adiposity) in the present study may only partially represent the effect of visceral fat, there may be a residual confounding from visceral obesity in our result. Longitudinal follow-up studies are necessary to confirm the association between sleep-disordered breathing and impaired glucose tolerance and to examine the causal relationship in a healthy population without obesity and diabetes.
AB - Hemoglobin A1c (HbA1c) is an indicator of long-term glycemic control. The purpose of this study was to determine whether habitual snoring is associated with increased HbA1c levels in non-obese and normoglycemic middle-aged men and women. A total of 6981 subjects (3362 men and 3619 women) aged 40-69 years from the Korean Health and Genome Study were examined for the study. Each participant received a comprehensive physical examination as well as a set of questions pertaining to demographic characteristics and snoring frequency. Habitual snoring was defined as a snoring frequency of ≥4 days week-1. After adjusting for age, abdominal obesity, and other confounding covariates, male habitual snorers showed a 1.69-fold excess [95% confidence interval (CI) 1.30-2.19] odds of having a high HbA1c level. Similarly, premenopausal women with habitual snoring had a 2.31 times (95% CI 1.22-4.39) significantly higher odds of having elevated HbA1clevels compared with non-snorers. This association was not found in postmenopausal women. Multivariate analysis revealed that male habitual snorers aged 40-50 had a 2.08-fold excess (95% CI 1.40-3.09) risk of having an elevated HbA1c level. In male habitual snores over 50, the strength of association was attenuated. Our findings based on cross-sectional data support a hypothesis that habitual snoring is associated with impaired glucose tolerance even in non-obese and normoglycemic men and premenopausal women. However, as waist circumference as an index of abdominal obesity (visceral adiposity) in the present study may only partially represent the effect of visceral fat, there may be a residual confounding from visceral obesity in our result. Longitudinal follow-up studies are necessary to confirm the association between sleep-disordered breathing and impaired glucose tolerance and to examine the causal relationship in a healthy population without obesity and diabetes.
KW - Hemoglobin a
KW - Impaired glucose tolerance
KW - Menopause
KW - Sleep disorders
UR - http://www.scopus.com/inward/record.url?scp=33751167181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33751167181&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2869.2006.00556.x
DO - 10.1111/j.1365-2869.2006.00556.x
M3 - Article
C2 - 17118101
AN - SCOPUS:33751167181
VL - 15
SP - 437
EP - 444
JO - Journal of Sleep Research
JF - Journal of Sleep Research
SN - 0962-1105
IS - 4
ER -