Haemocompatibility evaluation of silica nanomaterials using hemorheological measurements

Jeongho Kim, Yu Jin Heo, Sehyun Shin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Silica nanomaterials (NMs) are widely used in semiconductor, agriculture, cosmetics, and biomedical applications, in addition to other industries. We investigated the toxic effect of silica NMs on rheological characteristics of human red blood cells (RBCs), including hemolysis, deformability, aggregation, and morphological changes. Red blood cells were exposed to silica nanoparticles (d=~200 nm) or silica nanowires (d=~200 nm, l=1μm or 10μm) at a range of concentrations and incubation times. Rheological characteristics were measured using microfluidic-laser diffractometry and aggregometry. Overall, at a concentration greater than 12.5μg/ml, the hemolytic activity was shown to be in the order of nanoparticles, short nanowires, and long nanowires. Elongation index (EI) values were insignificant in the RBCs exposed to each of the silica NMs at a concentration of 12.5μg/ml. Aggregation index (AI) values decreased in the short silica nanowires at a concentration of 12.5μg/ml compared to other silica NMs. Therefore, the safe concentration of silica NMs for toxicity, in this study, was considered less than 12.5μg/ml. These hemorheological results provided insight into the interaction between RBCs and silica NMs; they will also help assess the risk of NMs' toxicity in the blood.

Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalClinical Hemorheology and Microcirculation
Volume62
Issue number2
DOIs
Publication statusPublished - 2016 Mar 18

Fingerprint

Nanostructures
Silicon Dioxide
Nanowires
Erythrocytes
Nanoparticles
Semiconductors
Microfluidics
Poisons
Hemolysis
Agriculture
Cosmetics
Industry
Lasers

Keywords

  • hemorheology
  • nanomaterials
  • Silica
  • toxicity

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Haemocompatibility evaluation of silica nanomaterials using hemorheological measurements. / Kim, Jeongho; Heo, Yu Jin; Shin, Sehyun.

In: Clinical Hemorheology and Microcirculation, Vol. 62, No. 2, 18.03.2016, p. 99-107.

Research output: Contribution to journalArticle

@article{7c75dde8c1344894bfd2c7ea449c1f0d,
title = "Haemocompatibility evaluation of silica nanomaterials using hemorheological measurements",
abstract = "Silica nanomaterials (NMs) are widely used in semiconductor, agriculture, cosmetics, and biomedical applications, in addition to other industries. We investigated the toxic effect of silica NMs on rheological characteristics of human red blood cells (RBCs), including hemolysis, deformability, aggregation, and morphological changes. Red blood cells were exposed to silica nanoparticles (d=~200 nm) or silica nanowires (d=~200 nm, l=1μm or 10μm) at a range of concentrations and incubation times. Rheological characteristics were measured using microfluidic-laser diffractometry and aggregometry. Overall, at a concentration greater than 12.5μg/ml, the hemolytic activity was shown to be in the order of nanoparticles, short nanowires, and long nanowires. Elongation index (EI) values were insignificant in the RBCs exposed to each of the silica NMs at a concentration of 12.5μg/ml. Aggregation index (AI) values decreased in the short silica nanowires at a concentration of 12.5μg/ml compared to other silica NMs. Therefore, the safe concentration of silica NMs for toxicity, in this study, was considered less than 12.5μg/ml. These hemorheological results provided insight into the interaction between RBCs and silica NMs; they will also help assess the risk of NMs' toxicity in the blood.",
keywords = "hemorheology, nanomaterials, Silica, toxicity",
author = "Jeongho Kim and Heo, {Yu Jin} and Sehyun Shin",
year = "2016",
month = "3",
day = "18",
doi = "10.3233/CH-151953",
language = "English",
volume = "62",
pages = "99--107",
journal = "Clinical Hemorheology and Microcirculation",
issn = "1386-0291",
publisher = "IOS Press",
number = "2",

}

TY - JOUR

T1 - Haemocompatibility evaluation of silica nanomaterials using hemorheological measurements

AU - Kim, Jeongho

AU - Heo, Yu Jin

AU - Shin, Sehyun

PY - 2016/3/18

Y1 - 2016/3/18

N2 - Silica nanomaterials (NMs) are widely used in semiconductor, agriculture, cosmetics, and biomedical applications, in addition to other industries. We investigated the toxic effect of silica NMs on rheological characteristics of human red blood cells (RBCs), including hemolysis, deformability, aggregation, and morphological changes. Red blood cells were exposed to silica nanoparticles (d=~200 nm) or silica nanowires (d=~200 nm, l=1μm or 10μm) at a range of concentrations and incubation times. Rheological characteristics were measured using microfluidic-laser diffractometry and aggregometry. Overall, at a concentration greater than 12.5μg/ml, the hemolytic activity was shown to be in the order of nanoparticles, short nanowires, and long nanowires. Elongation index (EI) values were insignificant in the RBCs exposed to each of the silica NMs at a concentration of 12.5μg/ml. Aggregation index (AI) values decreased in the short silica nanowires at a concentration of 12.5μg/ml compared to other silica NMs. Therefore, the safe concentration of silica NMs for toxicity, in this study, was considered less than 12.5μg/ml. These hemorheological results provided insight into the interaction between RBCs and silica NMs; they will also help assess the risk of NMs' toxicity in the blood.

AB - Silica nanomaterials (NMs) are widely used in semiconductor, agriculture, cosmetics, and biomedical applications, in addition to other industries. We investigated the toxic effect of silica NMs on rheological characteristics of human red blood cells (RBCs), including hemolysis, deformability, aggregation, and morphological changes. Red blood cells were exposed to silica nanoparticles (d=~200 nm) or silica nanowires (d=~200 nm, l=1μm or 10μm) at a range of concentrations and incubation times. Rheological characteristics were measured using microfluidic-laser diffractometry and aggregometry. Overall, at a concentration greater than 12.5μg/ml, the hemolytic activity was shown to be in the order of nanoparticles, short nanowires, and long nanowires. Elongation index (EI) values were insignificant in the RBCs exposed to each of the silica NMs at a concentration of 12.5μg/ml. Aggregation index (AI) values decreased in the short silica nanowires at a concentration of 12.5μg/ml compared to other silica NMs. Therefore, the safe concentration of silica NMs for toxicity, in this study, was considered less than 12.5μg/ml. These hemorheological results provided insight into the interaction between RBCs and silica NMs; they will also help assess the risk of NMs' toxicity in the blood.

KW - hemorheology

KW - nanomaterials

KW - Silica

KW - toxicity

UR - http://www.scopus.com/inward/record.url?scp=84961844586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961844586&partnerID=8YFLogxK

U2 - 10.3233/CH-151953

DO - 10.3233/CH-151953

M3 - Article

C2 - 26410861

AN - SCOPUS:84961844586

VL - 62

SP - 99

EP - 107

JO - Clinical Hemorheology and Microcirculation

JF - Clinical Hemorheology and Microcirculation

SN - 1386-0291

IS - 2

ER -