Harnessing the Therapeutic Potential of Extracellular Vesicles for Biomedical Applications Using Multifunctional Magnetic Nanomaterials

Letao Yang, Kapil D. Patel, Christopher Rathnam, Ramar Thangam, Yannan Hou, Heemin Kang, Ki Bum Lee

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Extracellular vesicles (e.g., exosomes) carrying various biomolecules (e.g., proteins, lipids, and nucleic acids) have rapidly emerged as promising platforms for many biomedical applications. Despite their enormous potential, their heterogeneity in surfaces and sizes, the high complexity of cargo biomolecules, and the inefficient uptake by recipient cells remain critical barriers for their theranostic applications. To address these critical issues, multifunctional nanomaterials, such as magnetic nanomaterials, with their tunable physical, chemical, and biological properties, may play crucial roles in next-generation extracellular vesicles (EV)-based disease diagnosis, drug delivery, tissue engineering, and regenerative medicine. As such, one aims to provide cutting-edge knowledge pertaining to magnetic nanomaterials-facilitated isolation, detection, and delivery of extracellular vesicles and their associated biomolecules. By engaging the fields of extracellular vesicles and magnetic nanomaterials, it is envisioned that their properties can be effectively combined for optimal outcomes in biomedical applications.

Original languageEnglish
Article number2104783
JournalSmall
Volume18
Issue number13
DOIs
Publication statusPublished - 2022 Apr 1

Keywords

  • biosensors
  • exosomes
  • extracellular vesicles
  • magnetic nanomaterials
  • nanobiotechnology
  • nanomedicine
  • theranostics

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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