HDAC signaling in neuronal development and axon regeneration

Yongcheol Cho, Valeria Cavalli

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

The development and repair of the nervous system requires the coordinated expression of a large number of specific genes. Epigenetic modifications of histones represent an essential principle by which neurons regulate transcriptional responses and adapt to environmental cues. The post-translational modification of histones by chromatin-modifying enzymes histone acetyltransferases (HATs) and histone deacetylases (HDACs) shapes chromatin to adjust transcriptional profiles during neuronal development. Recent observations also point to a critical role for histone acetylation and deacetylation in the response of neurons to injury. While HDACs are mostly known to attenuate transcription through their deacetylase activity and their interaction with co-repressors, these enzymes are also found in the cytoplasm where they display transcription-independent activities by regulating the function of diverse proteins. Here we discuss recent studies that go beyond the traditional use of HDAC inhibitors and have begun to dissect the roles of individual HDAC isoforms in neuronal development and repair after injury.

Original languageEnglish
Pages (from-to)118-126
Number of pages9
JournalCurrent Opinion in Neurobiology
Volume27
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Histone Deacetylases
Axons
Regeneration
Histones
Chromatin
Histone Code
Histone Acetyltransferases
Neurons
Co-Repressor Proteins
Wounds and Injuries
Enzymes
Post Translational Protein Processing
Acetylation
Epigenomics
Nervous System
Cues
Protein Isoforms
Cytoplasm
Genes
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

HDAC signaling in neuronal development and axon regeneration. / Cho, Yongcheol; Cavalli, Valeria.

In: Current Opinion in Neurobiology, Vol. 27, 01.01.2014, p. 118-126.

Research output: Contribution to journalReview article

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