Healing effects of rebamipide and omeprazole in helicobacter pylori-positive gastric ulcer patients after eradication therapy: A randomized double-blind, multinational, multi-institutional comparative study

Kyung Ho Song, Yong Chan Lee, Dai Ming Fan, Zhi Zheng Ge, Feng Ji, Min Hu Chen, Hyun Chae Jung, Jiang Bo, Sang Woo Lee, Jin Ho Kim

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Background and Aims: A recent placebo-controlled trial showed that rebamipide, which is a mucosal-protective antiulcer agent, promoted gastric ulcer healing without affecting the Helicobacter pylori status. We conducted a randomized, double-blind trial to compare the healing effects of rebamipide and the proton-pump inhibitor omeprazole in H. pylori-positive gastric ulcers after H. pylori eradication therapy. Methods: After completion of 1 week of eradication therapy, 132 patients with H. pylori-positive gastric ulcer were enrolled in 5 Chinese and 4 Korean institutions. Patients were randomly assigned to take either 20 mg of omeprazole (n = 63) or 300 mg of rebamipide (n = 65) daily for 7 weeks. Healing was defined as complete recovery and S1 and S2 stage ulcer according to the Sakita-Miwa classification. Results: Healing rates at 12 weeks were 81.5% (53/65) and 82.5% (52/63) in the rebamipide and omeprazole groups, respectively. There was no significant difference in treatment efficacy, as evidenced by gastric ulcer healing rates (absolute difference-1.0%; 95% confidence interval-10.7 to 8.7; p = 0.88). The H. pylori eradication rate and ulcer healing rate did not differ between the groups, the latter regardless of eradication outcome. Conclusions: Rebamipide is as effective as omeprazole in treating of H. pylori-positive gastric ulcer after eradication therapy.

Original languageEnglish
Pages (from-to)221-229
Number of pages9
Issue number3
Publication statusPublished - 2011 Oct 1



  • Gastric ulcer
  • Helicobacter pylori
  • Omeprazole
  • Proton pump inhibitor
  • Rebamipide
  • Treatment efficacy

ASJC Scopus subject areas

  • Gastroenterology

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