Healing effects of rebamipide and omeprazole in helicobacter pylori-positive gastric ulcer patients after eradication therapy: A randomized double-blind, multinational, multi-institutional comparative study

Kyung Ho Song, Yong Chan Lee, Dai Ming Fan, Zhi Zheng Ge, Feng Ji, Min Hu Chen, Hyun Chae Jung, Jiang Bo, Sang Woo Lee, Jin Ho Kim

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Background and Aims: A recent placebo-controlled trial showed that rebamipide, which is a mucosal-protective antiulcer agent, promoted gastric ulcer healing without affecting the Helicobacter pylori status. We conducted a randomized, double-blind trial to compare the healing effects of rebamipide and the proton-pump inhibitor omeprazole in H. pylori-positive gastric ulcers after H. pylori eradication therapy. Methods: After completion of 1 week of eradication therapy, 132 patients with H. pylori-positive gastric ulcer were enrolled in 5 Chinese and 4 Korean institutions. Patients were randomly assigned to take either 20 mg of omeprazole (n = 63) or 300 mg of rebamipide (n = 65) daily for 7 weeks. Healing was defined as complete recovery and S1 and S2 stage ulcer according to the Sakita-Miwa classification. Results: Healing rates at 12 weeks were 81.5% (53/65) and 82.5% (52/63) in the rebamipide and omeprazole groups, respectively. There was no significant difference in treatment efficacy, as evidenced by gastric ulcer healing rates (absolute difference-1.0%; 95% confidence interval-10.7 to 8.7; p = 0.88). The H. pylori eradication rate and ulcer healing rate did not differ between the groups, the latter regardless of eradication outcome. Conclusions: Rebamipide is as effective as omeprazole in treating of H. pylori-positive gastric ulcer after eradication therapy.

    Original languageEnglish
    Pages (from-to)221-229
    Number of pages9
    JournalDigestion
    Volume84
    Issue number3
    DOIs
    Publication statusPublished - 2011 Oct

    Keywords

    • Gastric ulcer
    • Helicobacter pylori
    • Omeprazole
    • Proton pump inhibitor
    • Rebamipide
    • Treatment efficacy

    ASJC Scopus subject areas

    • Gastroenterology

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