Healthy range for serum ALT and the clinical significance of "unhealthy" normal ALT levels in the Korean population

Hyun Seok Kang, Soon-Ho Um, Yeon Seok Seo, Hyonggin An, Kwang Gyun Lee, Jong Jin Hyun, Eun-Sun Kim, Sung Chul Park, Bora Keum, Ji Hoon Kim, Hyung Joon Yim, Yoon Tae Jeen, Hong Sik Lee, Hoon-Jai Chun, Chang Duck Kim, Ho Sang Ryu

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Abstract

Background and Aims: It remains unclear whether the currently-used normal range for serum alanine aminotransferase (ALT) levels really reflects a healthy liver. The present study was conducted to evaluate the healthy range of serum ALT in the Korean adult population and to determine the clinical significance of unhealthy levels. Methods: We reviewed the medical records, including questionnaires and the results of laboratory and radiological tests conducted at the Health Promotion Center at Korea University Anam Hospital between March 2005 and February 2007. The records, written in questionnaire form, included baseline data, such as physical status, social behaviors, medication history, and past and present disease histories. Results: The mean age of the 7403 enrolled patients was 48years, and 49.9% of these patients were male. A healthy cohort was selected after excluding patients who showed any abnormalities of the factors that were significantly associated with the serum ALT level upon multivariate regression analysis. The upper limit of the healthy range of the serum ALT level (i.e. 95th percentile) in the healthy population was 31IU/L for males and 23IU/L for females. The prevalence of metabolic syndrome and insulin resistance (IR) were significantly higher in patients with an 'unhealthy' normal ALT level than in those with a healthy ALT level. Conclusion: In our study, the upper limit of the healthy range of the serum ALT level was 31IU/L for males and 23IU/L for females. An unhealthy normal ALT level was associated with a higher prevalence of metabolic syndrome and IR.

Original languageEnglish
Pages (from-to)292-299
Number of pages8
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume26
Issue number2
DOIs
Publication statusPublished - 2011 Jan 1

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Alanine Transaminase
Serum
Population
Insulin Resistance
Social Behavior
Korea
Health Promotion
Medical Records
Reference Values
Multivariate Analysis
Regression Analysis
Liver

Keywords

  • Aminotransferase
  • Insulin resistance
  • Metabolic syndrome
  • Non-alcoholic fatty liver disease

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

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title = "Healthy range for serum ALT and the clinical significance of {"}unhealthy{"} normal ALT levels in the Korean population",
abstract = "Background and Aims: It remains unclear whether the currently-used normal range for serum alanine aminotransferase (ALT) levels really reflects a healthy liver. The present study was conducted to evaluate the healthy range of serum ALT in the Korean adult population and to determine the clinical significance of unhealthy levels. Methods: We reviewed the medical records, including questionnaires and the results of laboratory and radiological tests conducted at the Health Promotion Center at Korea University Anam Hospital between March 2005 and February 2007. The records, written in questionnaire form, included baseline data, such as physical status, social behaviors, medication history, and past and present disease histories. Results: The mean age of the 7403 enrolled patients was 48years, and 49.9{\%} of these patients were male. A healthy cohort was selected after excluding patients who showed any abnormalities of the factors that were significantly associated with the serum ALT level upon multivariate regression analysis. The upper limit of the healthy range of the serum ALT level (i.e. 95th percentile) in the healthy population was 31IU/L for males and 23IU/L for females. The prevalence of metabolic syndrome and insulin resistance (IR) were significantly higher in patients with an 'unhealthy' normal ALT level than in those with a healthy ALT level. Conclusion: In our study, the upper limit of the healthy range of the serum ALT level was 31IU/L for males and 23IU/L for females. An unhealthy normal ALT level was associated with a higher prevalence of metabolic syndrome and IR.",
keywords = "Aminotransferase, Insulin resistance, Metabolic syndrome, Non-alcoholic fatty liver disease",
author = "Kang, {Hyun Seok} and Soon-Ho Um and Seo, {Yeon Seok} and Hyonggin An and Lee, {Kwang Gyun} and Hyun, {Jong Jin} and Eun-Sun Kim and Park, {Sung Chul} and Bora Keum and Kim, {Ji Hoon} and Yim, {Hyung Joon} and Jeen, {Yoon Tae} and Lee, {Hong Sik} and Hoon-Jai Chun and Kim, {Chang Duck} and Ryu, {Ho Sang}",
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T1 - Healthy range for serum ALT and the clinical significance of "unhealthy" normal ALT levels in the Korean population

AU - Kang, Hyun Seok

AU - Um, Soon-Ho

AU - Seo, Yeon Seok

AU - An, Hyonggin

AU - Lee, Kwang Gyun

AU - Hyun, Jong Jin

AU - Kim, Eun-Sun

AU - Park, Sung Chul

AU - Keum, Bora

AU - Kim, Ji Hoon

AU - Yim, Hyung Joon

AU - Jeen, Yoon Tae

AU - Lee, Hong Sik

AU - Chun, Hoon-Jai

AU - Kim, Chang Duck

AU - Ryu, Ho Sang

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background and Aims: It remains unclear whether the currently-used normal range for serum alanine aminotransferase (ALT) levels really reflects a healthy liver. The present study was conducted to evaluate the healthy range of serum ALT in the Korean adult population and to determine the clinical significance of unhealthy levels. Methods: We reviewed the medical records, including questionnaires and the results of laboratory and radiological tests conducted at the Health Promotion Center at Korea University Anam Hospital between March 2005 and February 2007. The records, written in questionnaire form, included baseline data, such as physical status, social behaviors, medication history, and past and present disease histories. Results: The mean age of the 7403 enrolled patients was 48years, and 49.9% of these patients were male. A healthy cohort was selected after excluding patients who showed any abnormalities of the factors that were significantly associated with the serum ALT level upon multivariate regression analysis. The upper limit of the healthy range of the serum ALT level (i.e. 95th percentile) in the healthy population was 31IU/L for males and 23IU/L for females. The prevalence of metabolic syndrome and insulin resistance (IR) were significantly higher in patients with an 'unhealthy' normal ALT level than in those with a healthy ALT level. Conclusion: In our study, the upper limit of the healthy range of the serum ALT level was 31IU/L for males and 23IU/L for females. An unhealthy normal ALT level was associated with a higher prevalence of metabolic syndrome and IR.

AB - Background and Aims: It remains unclear whether the currently-used normal range for serum alanine aminotransferase (ALT) levels really reflects a healthy liver. The present study was conducted to evaluate the healthy range of serum ALT in the Korean adult population and to determine the clinical significance of unhealthy levels. Methods: We reviewed the medical records, including questionnaires and the results of laboratory and radiological tests conducted at the Health Promotion Center at Korea University Anam Hospital between March 2005 and February 2007. The records, written in questionnaire form, included baseline data, such as physical status, social behaviors, medication history, and past and present disease histories. Results: The mean age of the 7403 enrolled patients was 48years, and 49.9% of these patients were male. A healthy cohort was selected after excluding patients who showed any abnormalities of the factors that were significantly associated with the serum ALT level upon multivariate regression analysis. The upper limit of the healthy range of the serum ALT level (i.e. 95th percentile) in the healthy population was 31IU/L for males and 23IU/L for females. The prevalence of metabolic syndrome and insulin resistance (IR) were significantly higher in patients with an 'unhealthy' normal ALT level than in those with a healthy ALT level. Conclusion: In our study, the upper limit of the healthy range of the serum ALT level was 31IU/L for males and 23IU/L for females. An unhealthy normal ALT level was associated with a higher prevalence of metabolic syndrome and IR.

KW - Aminotransferase

KW - Insulin resistance

KW - Metabolic syndrome

KW - Non-alcoholic fatty liver disease

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